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Abstract XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules that
Highlights • Apo DdmD assembles as an autoinhibited dimer for plasmid nicking • DdmE is a DNA-guided, DNA-targeting Argonaute-like protein and prefers short guides •
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many
Highlights • Proteo-metabolomics predicts SDS dependency that is validated in patient tumor slices • OAT, GLS, and ALDH18A1 form an axis central to mitochondrial rewiring
Significance Since metabolic dysfunction-associated steatohepatitis (MASH) is the most common liver disease in the United States, the mechanisms underlying its regression are key to developing
Abstract For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1,2,3,4,5,6. However, how fasting and post-fast refeeding
Editor’s summary Alzheimer’s disease has been associated with brain metabolic alterations. Minhas et al. studied the role of glucose metabolism impairments on disease progression using a
Significance Synchronization between cells plays a critical role in cell-to-cell communication. Although electrical and chemical communications were studied, mechanical communication is recently recognized as a
Highlights Summary Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness
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