Abstract The obesity epidemic continues to worsen worldwide, driving metabolic and chronic inflammatory diseases. Thiazolidinediones, such as rosiglitazone (Rosi), are PPARγ agonists that promote ‘M2-like’
Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related
Brown fat the form of adipose tissue that burns, rather than stores, energy was only recently discovered to exist in adult humans. For decades, researchers
The hormone leptin, produced by fat cells, acts as a satiety signal to the brain, resulting in fat breakdown when levels are high. The hormone,
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