Abstract Human brains vary across people and over time; such variation is not yet understood in cellular terms. Here we describe a relationship between people’s
Abstract Tissues within an organism and even cell types within a tissue can age with different velocities. However, it is unclear whether cells of one
Highlights Summary Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and
Highlights Summary Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal
Abstract Haematopoietic ageing is marked by a loss of regenerative capacity and skewed differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production. Signals
More VEGF, more life span and health span Advanced aging is celebrated but its ill effects of deterioration at the cell, tissue, and organ levels
Aging sees many physiological changes. Studies are revealing the dynamics of the cells and molecular factors that contribute to the aging process. For example, chronological
Abstract Aging is associated with complex molecular and cellular processes that are poorly understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set
A new study published in Nature Communications shows that the age of bats can be predicted with high accuracy based on DNA methylation patterns. A
The metabolic features of many diseases have a striking overlap with cancer. The metabolism of diseases is an interconnected network. Connecting of cancer metabolism to
A central aspect of aging research concerns the question of when individuality in lifespan arises1. Here we show that a transient increase in reactive oxygen
A study of nematode worms, mice, and humans indicates that, across the animal kingdom, with aging comes more neural activity and when this natural increase
One day, doctors may be able to use the metabolites in blood samples to predict the likelihood of a person surviving another five to 10
DNA methylation status in a variety of tissues can accurately reveal the age of an animal, but previously discovered epigenetic clocks often aren’t evolutionarily conserved.
Cells from patients with Hutchinson-Gilford progeria syndrome (HGPS) have defects in nuclear architecture that lead to premature cellular senescence. … These results could also be
Researchers say they have mapped the gene expression of each individual brain cell during aging in the fruit fly. Their study (“A Single-Cell Transcriptome Atlas
People with Alzheimer’s have a higher production rate of tau proteins than healthy individuals, according to a study published today (March 21) in Neuron. While
In the 1990s, pharmacologist Dave Sharp of the University of Texas’s Barshop Institute for Longevity and Aging Studies in San Antonio was studying mice with
A new paper claims that there may be no such thing as a maximum life span for naked mole rats. As these burrowing, sausage-shaped rodents
A dietary supplement containing a blend of thirty vitamins and minerals–all natural ingredients widely available in health food stores–has shown remarkable anti-aging properties that can
Last year, Elizabeth Parrish, the CEO of Seattle-based biotech firm BioViva, hopped a plane to Colombia, where she received multiple injections of two experimental gene
Scientists studying the nematode wormCaenorhabditis elegans—an important model organism in aging research—often use a chemotherapy drug called FUdR to sterilize the worms and prevent them
In cells undergoing senescence, chromosomes tend to become more compact, according to a report published today (February 5) in Science Advances.This and other chromatin rearrangements
Highlights •The aging Drosophila intestine is genetically mosaic •Somatic recombination, genomic deletions, and rearrangements occur in aging ISCs •Somatic inactivation of the tumor-suppressor Notch causes
Jeanne Calment has nothing on Creme Puff, the cat. The oldest living human made it to the ripe age of 122 not bad for a
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