Highlights Summary The dominant risk factors for late-onset Alzheimer’s disease (AD) are advanced age and the APOE4 genetic variant. To examine how these factors alter neuroimmune function,
Significance Cyclin-dependent kinase 5 (Cdk5) hyperactivity is an important driver of pathology in neurodegeneration. Normally, Cdk5 is regulated by association with its co-activators p35 or p39.
Abstract Amyloid self-assembly is linked to numerous devastating cell-degenerative diseases. However, designing inhibitors of this pathogenic process remains a major challenge. Cross-interactions between amyloid-β peptide
Alzheimer’s disease (AD) is characterized by accumulation of misfolded proteins. Genetic studies implicate microglia, brain-resident phagocytic immune cells, in AD pathogenesis. As positive effectors, microglia
Targeting microglia with niacin Microglia have been shown to contribute in Alzheimer’s disease (AD) pathophysiology. However, the role of these cells remains to be completely
For decades, research into Alzheimer’s disease has centred on neurons. Only in the past few years have scientists identified a role for immune cells in
When Biogen and its partner Eisai announced in March that they’d halted two simultaneous Phase 3 clinical trials on an Alzheimer’s drug based on disappointing
Researchers have identified a genetic mutation that may help mitigate the risk of some forms of Alzheimer’s. In a study published yesterday (November 4) in
Researchers have found a link between RNA splicing alterations and tau-mediated neurodegeneration in Alzheimer’s disease. The study, published today (October 8) in Cell Reports, examined
There are approximately 5.6 million people over the age of 65 living with Alzheimer’s disease in the United States. With the population aging, that number
Tau is a structural protein of brain cells that, in various neurodegenerative conditions and as a result of brain injury, can accumulate as tangled toxic
For a small fold of tissue, the hippocampus has an outsized influence. It stores and retrieves human memories, capturing the life history that makes us
Sounds with a frequency of 40 hertz and lights that flicker at the same rate stimulate a pattern of brain activity known as gamma waves,
Researchers in the UK and New Zealand have created the largest-ever database of protein expression changes associated with Alzheimer’s disease, according to a study published
Traces of the bacterium Porphyromonas gingivalis, which causes chronic gum disease, have been found in the brains of people who had Alzheimer’s disease. The result
Levels of a protein called neurofilament light chain increase in the blood and spinal fluid of some Alzheimer’s patients 16 years before they develop symptoms,
Researchers injected mouse brains with a growth hormone tainted with amyloid-β, a protein implicated in Alzheimer’s disease, and saw it accumulate. The study, published yesterday
Neuroscientists have amassed more evidence for the hypothesis that sticky proteins that are a hallmark of neurodegenerative diseases can be transferred between people under particular
Mice that model a severe form of Alzheimer’s disease tend to exhibit improved memory after exercise-induced neuron production, according to a report in Science today
Ultrasound and microbubbles can safely open the blood-brain barrier in patients with Alzheimer’s disease, researchers reported yesterday (July 25) in Nature Communications and at the
An Alzheimer’s drug slows the rate of cognitive decline while reducing the amount of plaques in patients’ brains, according to the results of a clinical
In 1898, Camillo Golgi, an eminent Italian physician and pathologist, published a landmark paper on the structure of “nervous cells.” In addition to the organelle
People with Alzheimer’s have a higher production rate of tau proteins than healthy individuals, according to a study published today (March 21) in Neuron. While
With a large swath of the population entering its senior years, the number of Alzheimer’s disease (AD) cases are expected to skyrocket, placing a tremendous
Abstract BACE1 initiates the generation of the β-amyloid peptide, which likely causes Alzheimer’s disease (AD) when accumulated abnormally. BACE1 inhibitory drugs are currently being developed
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