Abstract Tissue injury to skin diminishes miR-200b in dermal fibroblasts. Fibroblasts are widely reported to directly reprogram into endothelial-like cells and we hypothesized that miR-200b
Highlights •Identified an allosteric pocket at the CDC42/RHOJ effector interaction interface •Used in silico methods to identify and optimize ARN22089, which binds to CDC42 •ARN22089 has broad
Abstract Vascular endothelial growth factors (VEGFs) are best known as key regulators of angiogenesis and lymphangiogenesis. Although VEGFs have been promising therapeutic targets for various
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
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