Significance Autoimmunity against melanoma differentiation–associated gene 5 (MDA5) induces fibrotic interstitial lung disease (ILD) in mice. In detail, MDA5-specific CD4+ T cells and virus infection-stimulated upregulation
Significance Amplification of MYC and mutation of p53 are frequently found in human cancers, yet directly targeting it has proven difficult. Thus, exploring alternative methods to hinder
Abstract Brain infiltration of peripheral immune cells and their interactions with brain-resident cells may contribute to Alzheimer’s disease (AD) pathology. To examine these interactions, in
Highlights Summary Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal
Significance Neurological diseases are often thought to be irreversible, including hearing loss. In this study, we found that one type of hearing loss can be
Summary Background Treatment options for premature ovarian insufficiency (POI) are limited to hormone replacement and donor oocytes. A novel induced pluripotent stem cell (iPSC) transplant
Abstract Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and
Abstract In myotonic dystrophy type 1 (DM1), deregulated alternative splicing of the muscle chloride channel Clcn1 causes myotonia, a delayed relaxation of muscles due to
Highlights •Tumor-specific T cells are necessary but not sufficient for therapeutic efficacy •IV vaccination promotes tumor regression by remodeling the TME •Systemic IFN-I following IV vaccination
Targeting microglia with niacin Microglia have been shown to contribute in Alzheimer’s disease (AD) pathophysiology. However, the role of these cells remains to be completely
Abstract The coronavirus disease 2019 (COVID-19) pandemic is having a catastrophic impact on human health1. Widespread community transmission has triggered stringent distancing measures with severe
Scientists at the Weizmann Institute of Science have identified a molecular pathway in the brain that can be targeted to reduce anxiety. Their studies showed
A compound found in the waxy coating of coffee beans may work in synergy with caffeine to protect against Parkinson’s disease (PD), according to research
Early phase Northwestern Medicine research published in the journal Proceedings of the National Academy of Sciences has demonstrated a potential new therapeutic strategy for treating
Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of
Countering TB prodrug resistance The arsenal of antibiotics for treating tuberculosis (TB) contains many prodrugs, such as ethionamide, which need activation by normal metabolism to
Neuroscientists have long debated how itch and pain overlap in the nervous system. Although itch was once thought to arise from the same neurons that
Vitamin B3 protects mice from glaucoma Glaucoma is the most common cause of age-related blindness in the United States. There is currently no cure, and
Engineering cells to regulate glucose Diabetes mellitus affects hundreds of millions of people worldwide. Blood glucose levels are chronically deregulated in diabetics, and this can
The blood disorder, β-thalassaemia, is considered an attractive target for gene correction. Site-specific triplex formation has been shown to induce DNA repair and thereby catalyse
In gene editing, the kindest cut may be no cut at all. This possibility was explored by researchers working with peptide nucleic acids (PNAs), synthetic
Zika virus has frightened people the world over because of growing evidence that it can have severe effects on fetuses when it infects pregnant women.
Selective delivery of copper (Cu) to the central nervous system effectively treats the motor neuron disease amyotrophic lateral sclerosis (ALS) in the most widely used
Precision medicine is all about the two T’s—targets and treatments—targets that emerge from analyses of patient-specific information, and treatments that hit these targets. Both T’s,
First out is a kidney: its dark red fades to beige as it is washed of its blood. The pancreas, harder to find amid the
Created by ePubSystems. Contact Us for similar site for your university or institute.