Abstract The discovery of novel structural classes of antibiotics is urgently needed to address the ongoing antibiotic resistance crisis1,2,3,4,5,6,7,8,9. Deep learning approaches have aided in
Abstract Bacteriophages operate via pathogen-specific mechanisms of action distinct from conventional, broad-spectrum antibiotics and are emerging as promising alternative antimicrobials. However, phage-mediated killing is often
Panning for antibiotics that stand out Despite their importance in modern medicine, antibiotics are under constant threat as pathogens adapt, acquire, or evolve resistance with
Abstract The emergence of drug-resistant bacteria calls for the discovery of new antibiotics. Yet, for decades, traditional discovery strategies have not yielded new classes of
Ever since the first cases of a mysterious disease in the early 1980s exploded into the HIV/AIDS pandemic, researchers have been searching for ways to
Summary Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a
Abstract Background Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the
In the summer of 1924, Calvin Jr., President Coolidge’s youngest son, developed a blister in his third right toe while playing tennis at the White
Escherichia coli is capable of synthesizing drug-resistant proteins even in the presence of antibiotics designed to cripple cell growth. That’s the finding by a group
Antibiotic-resistant infections could kill 2.4 million people in Europe, North America, and Australia by 2050 without further action to combat the infections, according to a
Probotics are a booming business, with sales in the billions of dollars each year and millions of customers in the US alone. Companies claim that
Some bacteria take antibiotic resistance a step further: they chow down on the very compounds designed to kill microbes and use them as fuel. Researchers
In 2014, Miriam van Staveren went on holiday to the Canary Islands and caught an infection. Her ear and sinuses throbbed, so she went to
Antibiotics are known to influence the growth of bacteria in the human body. But new research led by a team at the European Molecular Biology
With the world facing an anti-biotic-resistance crisis, the hunt is on for alternatives to fight bacterial infection. The quest has led peptide chemist Barney Bishop
Several factors have been identified that could be responsible for the collapse of honeybee populations. However, Raymann et al. have identified an antibiotic that appears
Update (March 13): In an open letter published last week (March 6), members of the Stop TB Partnership wrote that the WHO’s decision to leave
It’s another sign that an era of untreatable bacterial infections is inching closer. Today, the World Health Organization (WHO) released new guidelines for treating gonorrhea
Natural products have historically been of crucial importance in the identification and development of antibacterial agents. Interest in these systems has waned in recent years,
Patients who receive blood stem cells from a donor run a risk of developing immediate life-threatening infections and, a month or so later, graft-versus-host disease
n July 2011, a 43-year-old woman walked out of the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, after a month of battling
Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide threat to human health, because it is resistant to a large class of β-lactams (penicillins) and to second-generation
Researchers at the pharmaceutical company Merck have identified a new bacteria-killing compound with an unusual target—an RNA regulatory structure called a riboswitch. The team used
The emergence of antibiotic-resistant bacteria is a growing public health concern and has serious implications for both human and veterinary medicine. The nature of the
Bacteria that are commonly associated with respiratory and urinary tract infections in hospital settings, stand at the edge of a precipice waiting to plunge into
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