Abstract A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high
Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a WHO priority pathogen. Antibody-based medical countermeasures offer an important strategy to mitigate severe disease caused by CCHFV.
Summary Background Biliary tract cancers, which arise from the intrahepatic or extrahepatic bile ducts and the gallbladder, generally have a poor prognosis and are rising
Highlights • Prior S. aureus exposure makes the otherwise protective IsdB vaccine non-protective• IsdB vaccine recalls non-protective humoral memory from prior S. aureus infection• Specific antibody competition further reduces IsdB vaccine
Abstract Maternal autoantibody-related ASD (MAR ASD) is a subtype of autism in which pathogenic maternal autoantibodies (IgG) cross the placenta, access the developing brain, and
Abstract Immunosuppressive cells residing in the tumor microenvironment, especially tumor associated macrophages (TAMs), hinder the infiltration and activation of T cells, limiting the anti-cancer outcomes
Abstract The identification of the Omicron variant (B.1.1.529.1 or BA.1) of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in Botswana in November 20211 immediately raised alarms
Abstract Germinal centres (GC) are lymphoid structures where B cells acquire affinity-enhancing somatic hypermutations (SHM), with surviving clones differentiating into memory B cells (MBCs) and
A wide range of diseases have been shown to be influenced by the accumulation of senescent cells, from fibrosis to diabetes, cancer, Alzheimer’s and other
Abstract Uterine sensitization–associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1
Significance Phosphohistidine (pHis) is a labile posttranslational modification with two isoforms, 1-pHis and 3-pHis, involved in many cellular processes across the kingdoms of life. Due
Infection with the SARS-CoV-2 virus can lead to diverse outcomes, ranging from no symptoms to varying degrees of disease severity, spanning mild illness to death.
As the number of people who have fought off SARS-CoV-2 climbs ever higher, a critical question has grown in importance: How long will their immunity
When US President Donald Trump was ill with COVID-19, his physicians administered a bevy of medications — some proven, others experimental. But there is one
The results are in from the first monoclonal antibody drug for COVID-19 tested in humans. The small Phase 2 clinical trial involving 452 participants shows
A study of COVID-19 patients at two London hospitals has identified blood-based immunological changes that are linked to the disease and, in some cases, to
Immunoglobulin G (IgG) has been pinpointed as the likely culprit in hitherto unexplained cases of dangerous immune reactions known as anaphylaxis in response to anesthetic
Vaccines prevent millions of deaths a year and have pushed some diseases to the edge of existence. Yet it’s proven highly challenging, if not impossible,
Antiviral drugs prevent HIV from replicating, but the virus can hide in the cells of infected individuals in a non-replicating, latent form. A two-pronged approach
Adult human hippocampi are home to thousands of immature neurons, researchers report today (April 5) in Cell Stem Cell. The result runs counter to a
New neurons may not develop in the adult human brain as neuroscientists for years have come to believe. Researchers studying postmortem brain tissue of humans
In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The
In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The
Highlights Pre-existing antibodies to DENV1 correlate with high ZIKV neutralizing responses Antibodies to the EDIII lateral ridge correlate with serum neutralization of ZIKV Recurrent VH3-23/VK1-5
After decades of frustration, efforts to develop antibodies that can ferry drugs into cancer cells — and minimize damage to healthy tissue — are gathering
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