Highlights Summary Head and neck squamous cell carcinomas (HNSCCs) have high mortality and significant treatment-related morbidity. It is vital to discover effective, minimally invasive therapies
Highlights Abstract Tuberculosis (TB) accounts for 1.6 million deaths annually and over 25% of deaths due to antimicrobial resistance. Mycobacterium tuberculosis (M.tb) drives MCL-1 expression (family member of
Researchers have generally believed that the survival of neurons is determined nearly extrinsically, such as the tissues and cells that neurons supply with nerve cells.
Abstract Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body1, and regulates inflammation, cell proliferation, and tissue regeneration2,3,4. How apoptotic cells
Every day, billions of our cells die quietly and in an orderly fashion by activating a cell suicide program known as apoptosis. But others, often
In 2007, Ho Man “Holly” Tang took a break from her undergraduate biology studies at Iowa State University to join her older brother, Ho Lam
CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that,
p53 is an important tumor-suppressor protein that is mutated in more than 50% of cancers. Strategies for restoring normal p53 function are complicated by the
When cells in our body die, it is important that they are cleared from the system so that they do not cause inflammation or further
Abstract Activating mutations cartier love bracelet involving hermes belt the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest,
In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing
Apoptosis, necrosis, and pyroptosis The routes to cell death are many, and distinguishing which path a particular cell may have taken remains a challenge. Wallach
A protein embedded in the surface of mitochondria opens the door to apoptosis, causing cells to experience severe power failures, according to new work by
Scientists at the University of Texas Southwestern Medical Center report that they have targeted telomeres with a small molecule called 6-thiodG that takes advantage of
Long, non-coding regions of RNA can prevent red blood cells from committing suicide during the final stage of differentiation. Genes and Development (2011); Doi: 10.1101/gad.178780.111
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