Highlights Summary Background Patients with severe uncontrolled asthma represent a distinct endotype with persistent airway inflammation and remodeling that is refractory to corticosteroid treatment. CD4+ TH2
Abstract BACKGROUND Monoclonal antibodies targeting IgE, interleukin-4 and -13, and interleukin-5 are effective in treating severe type 2 asthma, but new targets are needed. Itepekimab
There are a lot of unknowns when it comes to understanding how the mammalian respiratory tract responds to allergens, but a study published today (January
Nature Genetics, 2011; DOI: 10.1038/ng.887 Mayumi Tamari et al. “Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population“. Researchers
Nature Genetics, 2011; DOI: 10.1038/ng.888 Carole Ober et al. “Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations“. A new national
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