Abstract Cancer cells feature a resting membrane potential (Vm) that is depolarized compared to normal cells, and express active ionic conductances, which factor directly in
RNA surveillance turns oncogenic Precise RNA regulation is a quality control mechanism that is important for normal development and to prevent disease. Aberrant RNAs require
Abstract Caspase-dependent apoptosis accounts for approximately 90% of homeostatic cell turnover in the body1, and regulates inflammation, cell proliferation, and tissue regeneration2,3,4. How apoptotic cells
Cellular metabolism is an interconnected network of chemical reactions, each step catalyzed by dedicated enzymes. Inhibition or intentional removal of an enzyme should grind the
CD95/Fas ligand binds to the death receptor CD95 to induce apoptosis in sensitive cells. We previously reported that CD95L mRNA is enriched in sequences that,
Aminoglycoside antibiotics bind to bacterial ribosomes and inhibit protein synthesis. Eukaryotic ribosomes, in contrast, are not strongly inhibited by these molecules but show errors such
Macrophages are innate immune cells that, when recruited to tumors, can promote tumor progression. Macrophage activity and phenotype can be influenced by molecules secreted by
When cells in our body die, it is important that they are cleared from the system so that they do not cause inflammation or further
Highlights •Different EGFR ligands stabilize receptor dimers with distinct structures •Epiregulin and epigen induce weaker and more short-lived EGFR dimers than EGF •Weakened dimerization causes
Abstract Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS
G-protein-coupled receptor (GPCR)-mediated signal transduction is central to human physiology and disease intervention, yet the molecular mechanisms responsible for ligand-dependent signalling responses remain poorly understood.
Targeting upstream phosphatidylinositol-3-kinases (PI3Ks) in the PI3K/Akt/mTOR pathway appears to be a promising therapy in solid cancers; however, first early clinical trials with PI3K inhibitors
Abstract Macrophages have diverse functions in immunity as well as development and homeostasis. Here we identify a function for these cells in long distance communication
Detailed maps of the immune cells that surround tumours could suggest fresh therapeutic targets, point out biological markers that can be used to select the
Rapid and simple assays to detect infectious agents are key to tracking emerging epidemics. Chotiwan et al. describe a loop-mediated amplification (LAMP) assay that detects
Give us our daily protein Protein is an essential component of our food, and protein intake thus must be actively regulated. Liu et al. identified
One means by which cancer cells evade therapies involves their ability to reprogram to a cell type that no longer depends on the cellular pathway
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the presence of
The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes. Cas9 creates double-strand
D2 dopamine receptors are targeted by antipsychotic agents to regulate behavior. Likhite et al. found putative arginine methylation motifs in some human G protein–coupled receptors
A protein embedded in the surface of mitochondria opens the door to apoptosis, causing cells to experience severe power failures, according to new work by
Immune cells constantly circulate in the body in search of pathogens or tissue damage. Because they move autonomously, immune cell trafficking must be tightly controlled
The origins of new fat cells (adipocytes), which we humans must make throughout our lives, have not been clear. Rodent studies have produced conflicting results
The physiological differences between males and females go far beyond reproduction; they may even include how an animal processes pain, according to a study published
Identifying the molecular mechanisms that underlie aging and their pharmacological manipulation are key aims for improving lifelong human health. Here, we identify a critical role
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