The 2010s brought major advancements in every aspect of the life sciences and ushered in an era of collaboration and multidisciplinary approaches. The Scientist spoke
Artificial intelligence tackles life science Look under the hood of many of this year’s headline-making discoveries in biology and you’ll find machine learning, a tool
Searching a sample of DNA for a particular sequence—be it a mutation, a researcher-inserted transgene, or evidence of an infecting organism—is a common practice in
Last month, the US Patent and Trademark Office reignited the infamous CRISPR patent dispute when it declared interference—overlapping intellectual property—between several pending patents belonging to
Two studies published yesterday (October 9) in Nature Medicine report success using modified CRISPR-Cas9 gene editing to prevent or cure two inherited diseases in mice.
Last Thursday (December 7), CRISPR Therapeutics submitted an application to European regulatory authorities seeking permission to begin clinical trials for CTX001, an investigational CRISPR treatment
Innovation comes in many forms, molded into various outlooks, adapted to shifting time frames. Sometimes, technological and conceptual progress is undergirded by a more expansive
Base editing is a relatively recent genome-editing technique that swaps one DNA base pair for another, offering researchers the potential to correct harmful, single-nucleotide mutations
Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called
In May 2012, the University of California, Berkeley, filed a patent application for biochemist Jennifer Doudna and the University of Vienna’s Emmanuelle Charpentier, then of
A team of Chinese researchers who were the first to report having applied CRISPR to human embryos have done it again—this time upgrading their technique
Circular RNAs (circRNAs) have attracted growing attention in recent years, but their function in living organisms has long remained a mystery. Now, researchers report that
Immune checkpoint inhibitor antibodies are a relatively new class of cancer drugs that are now approved to treat patients with late-stage melanoma and those with
Armed with a modified version of CRISPR-Cas9, scientists have removed nucleotide repeats from RNA in vitro that are known to cause diseases, namely, Huntington’s, ALS,
A minor proportion of people harbor a homozygous mutation in CCR5—a gene that encodes a receptor found on immune cells—that thwarts HIV’s attempts to get
Researchers have been studying the CRISPR-Cas9 gene-editing system as a potential therapeutic tool to modify or delete pathogenic sequences within the human genome. Now, using
A protein thought to be essential for cancer cells may not be so essential after all, according to a study published today (March 24) in
Delivering a CRISPR/Cas9–based therapy directly to the eye via a viral vector can prevent retinal degeneration in a mouse model of retinitis pigmentosa, a team
Microbes use a number of CRISPR-Cas systems for immunity, but it’s the class 2 system, typically utilizing the nuclease Cas9, that has been adapted for
Demonstrating yet another basic research application of CRISPR, two teams have independently reported scaled up CRISPR interference (CRISPRi) and CRISPR/Cas9 noncoding genomic screens. Researchers at MIT
Taking advantage of a deaminase enzyme that introduces a single nucleotide change to DNA, researchers have created a modified CRISPR/Cas9tool that avoids the generation of
Oncologist You Lu of Sichuan University’s West China Hospital in Chengdu and colleagues will soon begin trialing a new CRISPR-based immunotherapy in 10 patients with
CRISPR/Cas9 gene editing has shown remarkable therapeutic potential, including the ability to fightpathogens like HIV. But the same process that inactivates the deadly virus may
A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to
Retinitis pigmentosa, an inherited disease causing progressive degeneration of the retina, is repsonsible for blindness in approximately 1.5 million people worldwide. Using patient-derived stem cells,
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