Abstract BACKGROUND In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, the percentage
Highlights Abstract In the past 20 years, our understanding of the pathophysiology of depression has evolved from a focus on an imbalance of monoaminergic neurotransmitters
Abstract Increased inflammation in major depressive disorder (MDD) has been associated with low functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia, relationships
A growing body of literature ties the gut microbiome to symptoms of depression in a seemingly circular relationship where each affects the other. However, many of the studies
Abstract Background A growing body of research has demonstrated that adolescent offspring of depressed parents show diminished responding in the ventral striatum to reward. More
A cheap, widely available drug used to treat mental illness cuts both the risk of death from COVID-19 and the need for people with the
Deep brain stimulation can durably improve depression symptoms in people who don’t respond well to other treatments, according to a small study published last week
Imaging of neurons in the brains of living mice reveals how synapses between cells are eliminated in response to stress and reinstated by an antidepressant
The US Food and Drug Administration has approved esketamine to treat adults whose depression hasn’t responded to other antidepressants, the agency announced in a statement
We live in a medicated era. Recent data indicate that more than half of Americans are currently taking prescription drugs. Among pregnant women this number
Several hundred genes linked to intelligence or neuroticism have been reported in two separate studies conducted by the same group and published in Nature today
The anaesthetic drug ketamine also has a rapid antidepressant effect. Although ketamine is known to block N-methyl-D-aspartate (NMDA) receptors, its exact target—which brain region and
The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its mechanism of action
Psychiatric disorders display common patterns of gene expression, according to a study published today (February 8, 2018) in Science. Researchers have analyzed transcripts within the
“Expand your mind, man!” was a popular phrase that arose from the 1960’s counterculture movement. However, it was most likely not referring to the specific
Deep brain stimulation can visit this website improve debilitating, treatment-resistant brain disorders but involves surgically implanting electrodes that often have to penetrate multiple layers of
Summary points Depression is the leading mental health—related cause of the global burden of disease and is the focus of World Health Day 2017. Despite
Chronic stress or pain is associated with the development of depression. Descalzi et al. examined gene expression changes in the brain in mouse models of
Anti-inflammatory drugs similar to those used to treat conditions such as rheumatoid arthritis and psoriasis could in future be used to treat some cases of
Researchers at the Vollum Institute in Portland, Oregon, have resolved the crystal structures of the human serotonin transporter (SERT) bound to two different antidepressant drugs.
In the depths of February, many people living in wintry northern climes find themselves bummed out and craving the sunny days of summer. Now, researchers
To investigate the potential usefulness of artificial bright light in nonseasonal depression, investigators in Canada randomized 122 medication-free patients with moderately severe, nonpsychotic, nonbipolar major
A commonly prescribed antidepressant exerts epigenetic effects that may provide a useful biomarker of whether the drug works in patients. A team led by researchers
Researchers at the Centre for Addiction and Mental Health (CAMH) in Toronto have found a possible link between inflammation in the brain and clinical depression.
Researchers at Northwestern Medicine say they have developed the first blood test to diagnose major depression in adults. The assay, which works by measuring the levels of
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