Abstract The obesity epidemic continues to worsen worldwide, driving metabolic and chronic inflammatory diseases. Thiazolidinediones, such as rosiglitazone (Rosi), are PPARγ agonists that promote ‘M2-like’
Abstract Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting more than 16 million pregnancies annually worldwide1,2. GDM is related to an increased lifetime
Highlights Summary During the progression of type 1 diabetes (T1D), β cells are exposed to significant stress and, therefore, require adaptive responses to survive. The
Highlights Summary Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and
Abstract Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes1,2. Previous metagenomic studies have described the characteristics of gut microbiota and
Abstract Background and objectives: Previous studies have reported the protective effect of pioglitazone on dementia in type 2 diabetic mellitus (DM) patients. Recent studies have shown
Inhibition from the inside Inhibiting the receptor for advanced glycation end products (RAGE) has been shown to reduce complications of diabetes. Instead of targeting the
Abstract Despite many significant advances in 3D cell printing for skin, a disease model displaying the pathological processes present in the native skin has not
Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop
Biomedical engineers at Duke University have shown that the efficacy of a two-pronged type 2 diabetes treatment increases when the drugs are linked by a
Repaired β cells for replacement therapy Wolfram syndrome is a recessive genetic disease caused by mutations in WFS1 (Wolfram syndrome 1) and can present with a multitude
The metabolic features of many diseases have a striking overlap with cancer. The metabolism of diseases is an interconnected network. Connecting of cancer metabolism to
The islets of Langerhans in the pancreas contain insulin-secreting β-cells and glucagon-secreting α-cells. Insulin and glucagon are hormones that cooperate to regulate the levels of
An international team of researchers has successfully reprogrammed human α cells into insulin-producing β cells, according to a study published yesterday (February 13) in Nature.
A recent decrease in the incidence of type 1 diabetes in Australian children may be linked to the introduction of a routine vaccine against rotavirus,
Scientists have for the first time grown functioning human blood vessel organoids from stem cells in the lab. Their study, published on Wednesday (January 16)
A major cause of type 2 diabetes is obesity, in which fat cells expand rapidly, in both size and number, and their oxygen demand outstrips
Summary Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard
One strategy to treat type 1 diabetes, where the immune system destroys insulin-producing β cells, is to convert other cells into β-like cells that then
Metabolic syndrome, leaky guts, and infection Metabolic syndrome often accompanies obesity and hyperglycemia and is associated with a breakdown in the integrity of the intestinal
What is a best-selling drug worth? In 2013, at least, it came down to at least $3 billion in annual sales—triple the $1 billion benchmark
Prior research has found that drinking a glass of red wine a day may protect against cardiovascular diseases, diabetes, and neurodegenerative disorders. The latest laboratory
Most mammalian cells have a primary cilium, an antenna-like, immobile surface projection that senses the surrounding environment. Researchers report in Nature Genetics today (January 8)
Researchers have successfully treated animals with a mouse version of type 1 diabetes by inducing pancreatic cells that don’t normally produce insulin to manufacture the
Stemming attacks on the pancreas In type 1 diabetes, autoreactive CD4 T cells attack and kill pancreatic β cells, disrupting insulin production. Many approaches have
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