Highlights Summary Immune rejection has long hindered allogeneic cell transplantation therapy. Current genetic modification approaches, including direct targeting of major histocompatibility complex or constitutive expression
Summary The first step of oncogenesis is the acquisition of a repertoire of genetic mutations to initiate and sustain the malignancy. An important example of this initiation phase
Abstract The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol1. The central channel of the
Abstract The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific, but overall
Abstract Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the microbiome
Abstract Although antisense transcription is a widespread event in the mammalian genome, double-stranded RNA (dsRNA) formation between sense and antisense transcripts is very rare and
Highlights • Visualization of genes highly expressed in a cell cluster is a challenge.• Existing data embedding methods do not easily depict genes characterizing a
Abstract Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new
Abstract The remarkable genetic heterogeneity of multiple myeloma poses a substantial challenge for proper prognostication and clinical management of patients. Here, we introduce MM-PSN, the
A new study headed by researchers at the Institute for Research in Biomedicine (IRB) has uncovered how palmitic acid (PA)—a fatty acid commonly found in
Abstract A key driver of patients’ well-being and clinical trials for Parkinson’s disease (PD) is the course that the disease takes over time (progression and
As of today (January 23), 18 people have died from a newly identified coronavirus, and more than 630 have been infected. Airports are screening passengers
From Alaska down to the Baja Peninsula, the rocky tide pools of North America’s West Coast are separated by hundreds of kilometers of sandy beaches.
Koalas are susceptible to cancers such as lymphoma and leukemia along with chlamydia infections due to koala retrovirus, a pathogen that began inserting itself into
Scientists extracted a near-complete HIV-1 genome from a lymph node that had been preserved in wax for more than 50 years. The sample stands as
The great white shark genome—like the animal itself—is giant, with 41 pairs of chromosomes compared to humans’ 23 pairs, researchers reported yesterday (January 18) in
The majority of babies born in the US undergo a hearing screening as well as a blood test to detect certain diseases that can be
A group of genome researchers is making the case for sequencing the genomes of all eukaryotic species within ten years, predicting that it would benefit
nfection with the parasite Plasmodium falciparum causes malaria. Individuals may be infected with multiple strains of P. falciparum, some of which may be drug-resistant. Understanding
Summary By sequencing and comparing hundreds of bacterial genomes, researchers have shown that all of the explosive epidemics of cholera in Africa and the Americas
Summary By sequencing and comparing hundreds of bacterial genomes, researchers have shown that all of the explosive epidemics of cholera in Africa and the Americas
Cells respond to metabolic fluctuations by adjusting the speed of DNA replication as a safeguard for genome stability. Somyajit et al. elucidate the cellular mechanisms
Last week, word got out that a team of scientists had edited viable human embryos for the first time in the United States. Details of
Over the bracelets past decade, the ability to recover whole genomes from ancient remains has emerged as a powerful tool for understanding the human past.
BACKGROUNDAmong patients with non–small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome official website evolution have been limited to small retrospective cohorts. We
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