Highlights • Large-scale scRNA-seq study of human iPSC-derived retinal organoids• 23 subpopulations spread across 247,520 cells• Identified 312 significant eQTLs specific to retinal ganglion cells•
Highlights •Excitotoxic and axonal injuries lead to loss of CaMKII activity in RGCs •Reactivation of CaMKII protects RGCs in multiple injury/disease models •CREB acts downstream
Researchers used gene therapy to regenerate damaged axons in the eye, in a discovery that could aid the development of new treatments for glaucoma, one
Advancing age predisposes us to a number of neurodegenerative diseases, yet the underlying mechanisms are poorly understood. With some 70 million individuals affected, glaucoma is
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