Significance While rapalogs have been thought to function primarily by suppressing mTORC1 in kidney cancer cells, we show that mTORC1 inhibition of nontumor cells is
Abstract Purpose: Patients with resected localized clear-cell renal cell carcinoma (ccRCC) remain at variable risk of recurrence. Incorporation of biomarkers may refine risk prediction and
Abstract Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer.
Highlights •First synonymous BAP1 mutation that leads to exon skipping and loss of function •Exon 11 skipping is a hotspot for BAP1 inactivation •First synonymous mutation reported
Clear cell renal cell carcinoma, the most common form of kidney cancer, is usually linked to inactivation of the pVHL tumour suppressor protein and consequent
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