Abstract Despite the prominent role of the K-Ras protein in many different types of human cancer, major gaps in atomic-level information severely limit our understanding
Abstract HER2 mutations drive the growth of a subset of breast cancers and are targeted with HER2 tyrosine kinase inhibitors (TKI) such as neratinib. However, acquired
Highlights • L108F in MPXV DNA polymerase emerged in the 2022 outbreak.• L108F can enhance DNA binding affinity, processivity and drug sensitivity of F8L.• Mutation
The Wnt-βcatenin signaling transduction pathway controls transcriptional programs that regulate processes such as stem cell renewal and cell differentiation, playing key roles in the processes
In response to antibiotic treatment, bacteria improve their odds of survival by increasing the rate of mutations in their genomes, giving them more chances to
The cells that circulate in the bloodstream perform various functions and, in adults, are derived from progenitor cells in the bone marrow. Mutations in the
Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most
On a sunny day near Perth, Australia, two-year-old Scarlett Whitmore stares intently at her left shoulder. With absolute concentration, she raises her head to look
Base editing is a relatively recent genome-editing technique that swaps one DNA base pair for another, offering researchers the potential to correct harmful, single-nucleotide mutations
Norton Thoracic Institute researchers believe they have discovered a new approach to treating an aggressive and difficult-to-treat type of lung cancer. They published their study
In what appear to be the largest RNAi screening efforts in cancer to date, two groups of scientists have tamped down the expression of thousands
For the first time, researchers report the use of the mutagenic chemical N-ethyl-N-nitrosourea (ENU) to conduct a genetic screen in pigs. The data reveal mutations
Two years ago, researchers at Johns Hopkins University School of Medicine analyzed data on 31 cancer types, finding that the number of stem cell divisions
Most genomic studies to date have focused on linking mutations to diseases. Taking a new approach, researchers studying the genomes of apparently healthy individuals identified
Dozens of genetic mutations are known to facilitate cancer progression, but metastasis doesn’t appear to be controlled by additional changes to the genome. A study
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