Highlights Summary Prion-like protein propagation is considered a common pathogenic mechanism in neurodegenerative diseases. Here we investigate the in vivo propagation pattern and aggregation state of mutant α-synuclein
Highlights Summary Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain aging remain poorly understood. Here, we conducted spatiotemporal
Significance Cyclin-dependent kinase 5 (Cdk5) hyperactivity is an important driver of pathology in neurodegeneration. Normally, Cdk5 is regulated by association with its co-activators p35 or p39.
Abstract We describe in vivo follow-up PET imaging and postmortem findings from an autosomal dominant Alzheimer’s disease (ADAD) PSEN1 E280A carrier who was also homozygous for the APOE3 Christchurch
Highlights •Superficial CA1 pyramidal neurons are overactive in epileptic rodents •Neurodegeneration-related gene signatures progress radially in the epileptic CA1 •Larger vulnerability of superficial CA1 pyramidal
Abstract Brain ageing is characterised by a decline in neuronal function and associated cognitive deficits. There is increasing evidence that myelin disruption is an important
Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1–3. The ageing brain is also vulnerable
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that have important homeostatic and disease-promoting functions1. However, little is known
People with the advanced form of multiple sclerosis (MS) called secondary progressive MS who took the drug siponimod for one to two years had improved
Unraveling axonal traffic jam The protease BACE1 participates in Aβ production and has been shown to accumulate in dystrophic neurons and contribute to axonal pathology
Highlights •A new probe, PM-PBB3, captures pathological tau deposits in vivo with high contrast •PM-PBB3 allows an individual-based identification of AD and non-AD tauopathies •Autopsy assays of PET-scanned
Three studies presented at the Alzheimer’s Association International Conference this week describe the performance of blood tests used to diagnose, and even predict, Alzheimer’s disease using circulating
Researchers have generally believed that the survival of neurons is determined nearly extrinsically, such as the tissues and cells that neurons supply with nerve cells.
Amyotrophic lateral sclerosis (ALS) is a debilitating and fatal disorder that can be caused by mutations in the superoxide dismutase 1 (SOD1) gene. Although ALS
Researchers have found a link between RNA splicing alterations and tau-mediated neurodegeneration in Alzheimer’s disease. The study, published today (October 8) in Cell Reports, examined
There are approximately 5.6 million people over the age of 65 living with Alzheimer’s disease in the United States. With the population aging, that number
Tau is a structural protein of brain cells that, in various neurodegenerative conditions and as a result of brain injury, can accumulate as tangled toxic
In a mouse model of amyotrophic lateral sclerosis, animals that had ample levels the bacterium Akkermansia muciniphila in their gut microbiomes fared better than those
Sounds with a frequency of 40 hertz and lights that flicker at the same rate stimulate a pattern of brain activity known as gamma waves,
Levels of a protein called neurofilament light chain increase in the blood and spinal fluid of some Alzheimer’s patients 16 years before they develop symptoms,
Scientists from the Gladstone Institutes say they developed an antibody that blocks the inflammatory and oxidative activity of fibrin, which contributes to neurodegeneration in the
Aggregation of the protein tau is implicated in neurodegenerative diseases in humans. It emerges that eliminating a type of damaged cell that no longer divides
Mitochondrial dysfunction and subsequent metabolic deregulation is observed in neurodegenerative diseases and aging. Mutations in the presenilin (PSEN) encoding genes (PSEN1 and PSEN2) cause most
New neurons may not develop in the adult human brain as neuroscientists for years have come to believe. Researchers studying postmortem brain tissue of humans
Titanium dioxide nanowires coated in gold nanoparticles have restored blind mice’s ability to detect changes in light. The prosthetic, described today (March 6) in Nature
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