Abstract Obesity is a state of low-grade chronic inflammation that causes multiple metabolic diseases. During obesity, signalling via cytokines of the TNF family mediate cell
KEY POINTS pDCs follow a multi-step adhesion cascade to home to VAT that changes upon HFD. pDCs localize in lymphoid clusters with increased density and
Highlights •HFD augments intestinal stemness through PPARδ and PPARα •A PPAR-FAO program enhances stemness and tumorigenicity in a HFD •Loss or inhibition of Cpt1a-mediated FAO
The metabolic features of many diseases have a striking overlap with cancer. The metabolism of diseases is an interconnected network. Connecting of cancer metabolism to
Every man, woman, and mouse partakes in a different amount of voluntary physical activity. Some willingly run miles a day with no destination in mind,
When Sara Campbell first typed “exercise and microbiome” into PubMed in 2010 and hit enter, “the search literally said zero,” she tells The Scientist. Campbell
Children who are breastfed appear to be at a lower risk for obesity later in life. One explanation is that breast milk may somehow prevent
A major cause of type 2 diabetes is obesity, in which fat cells expand rapidly, in both size and number, and their oxygen demand outstrips
The activity in a cortical area involved in self-regulation was the best correlate of weight loss in a study published today (October 18) in Cell
Metabolic syndrome, leaky guts, and infection Metabolic syndrome often accompanies obesity and hyperglycemia and is associated with a breakdown in the integrity of the intestinal
Obese men with metastatic melanoma who are treated using targeted or immuno-therapies survive for more than twice as long as patients receiving the same treatment,
Most mammalian cells have a primary cilium, an antenna-like, immobile surface projection that senses the surrounding environment. Researchers report in Nature Genetics today (January 8)
Two people with a rare genetic disorder have helped shed light on the fundamental neuroscience of appetite and, scientists say, opened up a new target
Summary Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index
Overweight parents could be at risk of having children with impaired development, according to a study published January 3 in Pediatrics. Researchers found that children
Lose weight, gain it back. That’s the frustrating routine for many individuals who have experienced only short-term success with diets. To examine the microbial and
Attendees at the 2015 Genitourinary Cancers Symposium in Orlando, Florida, were presented with a head scratcher. At a poster session on renal cancer, a team
In mice, severely restricting caloric intake promotes the transformation of white fat into brown fat, which contains cells that burn energy faster, according to a
Obesity is more prevalent in patients with a history of cancer than in the general population and survivors of colorectal and breast cancers are particularly
ommon mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however direct evidence in support of this hypothesis is lacking. We therefore
Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying mechanism remains largely unknown. Here we showed that obesity-related
Researchers from University of California, Santa Barbara and UCLA report that millions of Americans labeled overweight or obese based on their body mass index (BMI)
Gorging oneself on high-calorie food to pack on fat only to fall asleep for a few months and have it all melt away isn’t the
Obese individuals have increased circulating levels of inflammatory cytokines produced by adipose tissue macrophages. Velmurugan et al. found that adipose tissue macrophages from obese mice
A team led by researchers from the University of Copenhagen discovered differences in the sperm epigenomes of lean and obese men, and in the sperm
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