Evolution-inspired engineering of nonribosomal peptide synthetases
Editor’s summary Many clinically used drugs are derived from natural microbial products that are assembled in a stepwise fashion by the condensation of amino acids
Editor’s summary Many clinically used drugs are derived from natural microbial products that are assembled in a stepwise fashion by the condensation of amino acids
Significance Gamete production requires tightly regulated interactions between the parental chromosomes, which coalign and exchange information. These events are mediated by the synaptonemal complex—a ladder-like
Editor’s summary Mutations in leucine-rich repeat kinase 2 (LRRK2) are implicated in the development of Parkinson’s disease, so this enzyme is a target for therapeutics
Abstract Tauopathies are a heterogenous group of neurodegenerative disorders characterized by tau aggregation in the brain. In a subset of tauopathies, rare mutations in the MAPT gene,
Highlights Summary Prion-like protein propagation is considered a common pathogenic mechanism in neurodegenerative diseases. Here we investigate the in vivo propagation pattern and aggregation state of mutant α-synuclein
Abstract Targeted protein degradation is an emerging strategy for the elimination of classically undruggable proteins. Here, to expand the landscape of targetable substrates, we designed
Highlights Summary The ability to map trafficking for thousands of endogenous proteins at once in living cells would reveal biology currently invisible to both microscopy
Abstract The breathing motions of proteins are thought to play a critical role in function. However, current techniques to study key collective motions are limited
Abstract The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol1. The central channel of the
Abstract Huntington’s disease is a neurodegenerative disorder caused by a CAG expansion in the first exon of the HTT gene, resulting in an extended polyglutamine (poly-Q) tract
Summary Background Emerging evidence shows that α-synuclein seed amplification assays (SAAs) have the potential to differentiate people with Parkinson’s disease from healthy controls. We used
Cell Press is proud to present papers from the Clinical Proteomic Tumor Analysis Consortium (CPTAC). This consortium is the National Cancer Institute’s initiative to accelerate
Highlights 16% of COVID-19 patients display an atypical low-inflammatory plasma proteome Severe COVID-19 is associated with heterogeneous plasma proteomic responses Death of virus-infected lung epithelial
Abstract Studies of gene‐targeted mice identified the roles of the different pro‐survival BCL‐2 proteins during embryogenesis. However, little is known about the role(s) of these
Scientists at Scripps Research have discovered a molecule that can activate a natural immune-boosting protein called STING. The findings mark a key advance in the
In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s
Our genetic material is littered with parasitic DNA sequences, known as transposons, which promote their own propagation and transmission, rather than their host’s1. Their movements
Each human cell contains so much DNA — about 2 metres if extended — that it must be tightly wrapped around specialized histone proteins to
Traces of the bacterium Porphyromonas gingivalis, which causes chronic gum disease, have been found in the brains of people who had Alzheimer’s disease. The result
Scientists at UW Medicine’s Institute for Protein Design (IPD) in Seattle have created a new protein that mimics the action of a key immune regulatory
In some patients with cancer, tumors don’t shrink in response to chemotherapy and these patients are more likely to develop metastatic cancer. Mouse studies have
Highlights • Sterols induce conformational change in Smoothened to activate Hedgehog signaling • The active Smoothened conformation resembles that of active G-protein-coupled receptors • Inactive
Ribonuclease P (RNase P) recognizes precursor transfer RNA (pre-tRNA) and processes it to generate mature tRNAs that are used for assembling proteins. Unlike almost all
Getting your appendix removed may reduce the risk of developing Parkinson’s disease, researchers report yesterday (October 31) in Science Translational Medicine. The team identified the
This year’s Nobel Prize in Chemistry was awarded to three scientists who harnessed evolution in the lab. Frances Arnold, a chemical engineer at the California
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