Editor’s summary RNA is generally considered a short-lived mediator of genetic information. Zocher et al. discovered that certain nuclear RNAs produced during postnatal development can persist
Abstract The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written around one third of the human genome through a “copy-and-paste” mechanism catalyzed
Editor’s summary Microbial biochemicals systems are incredibly diverse, and computational tools to analyze sequence data are essential in identifying new and valuable components for biotechnology
Abstract The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype–phenotype relationships in complex tissues in a high-throughput manner1,2.
Significance DNA and RNA deformations play crucial roles in biological processes, such as DNA packaging and nucleic acid recognition by proteins. The relevant understanding is
Highlights Summary The evolutionarily conserved minor spliceosome (MiS) is required for protein expression of ∼714 minor intron-containing genes (MIGs) crucial for cell-cycle regulation, DNA repair, and MAP-kinase signaling. We explored
Abstract Cell-free genetically encoded biosensors have been developed to detect small molecules and nucleic acids, but they have yet to be reliably engineered to detect
RNA surveillance turns oncogenic Precise RNA regulation is a quality control mechanism that is important for normal development and to prevent disease. Aberrant RNAs require
Highlights •An unbiased genetic screen identifies effectors of AKT signaling as regulators of NMD •AKT phosphorylation of UPF1 overcomes autoinhibition of UPF1 helicase activity •AKT
Abstract Class 2 CRISPR effectors Cas9 and Cas12 may have evolved from nucleases in IS200/IS605 transposons. IscB is about 2/5 the size of Cas9 but
Abstract RNA G-quadruplex (rG4)-SELEX is a method that generates L-RNA aptamers to target an rG4 structure of interest, which can be applied to inhibit G-quadruplex-mediated interactions
Abstract Cap-adjacent nucleotides of animal, protist and viral mRNAs can be O-methylated at the 2‘ position of the ribose (cOMe). The functions of cOMe in animals,
Abstract Large segmental osseous defects heal poorly. Recombinant, human bone morphogenetic protein-2 (rhBMP-2) is used clinically to promote bone healing, but it is applied at
Abstract Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden1. Yet the ability to assess underlying pathophysiology before
Abstract Vascular endothelial growth factors (VEGFs) are best known as key regulators of angiogenesis and lymphangiogenesis. Although VEGFs have been promising therapeutic targets for various
Identifying transcript location in cells Identifying where specific RNAs occur within a cell or tissue has been limited by technology and imaging capabilities. Expansion microscopy
SARS-CoV-2, the virus responsible for COVID-19, has wreaked havoc on health care systems, economies and everyday lives worldwide. Scientists are fighting back with multiple strategies,
Psoriasis, a chronic skin condition that causes itchy, red, scaly patches, afflicts more than 8 million Americans and 125 million people worldwide. Small molecule-based drugs
The development of broad-spectrum antiviral drugs particulary in the context of emerging zoonotic infections for which specific interventions do not exist sheahnan et al. tested
Although neurobiologist Oded Rechavi comes from a family of doctors and researchers, it was not his original plan to go into science. “It wasn’t something
Variation in the DNA sequences that constitute the blueprint of life is essential to the fitness of any species, yet thousands of DNA alterations are
Koalas are susceptible to cancers such as lymphoma and leukemia along with chlamydia infections due to koala retrovirus, a pathogen that began inserting itself into
Researchers have found a link between RNA splicing alterations and tau-mediated neurodegeneration in Alzheimer’s disease. The study, published today (October 8) in Cell Reports, examined
For the first time, scientists have found that complex sugars called glycans may bind to some RNA molecules, according to a bioRxiv preprint published September
Exposure of cells to acidic conditions outside the cell activates chloride-conducting channels that influence physiological and pathological processes. Yang et al. used an unbiased RNA
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