Abstract An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically identified by peptide sequences representing
Abstract The remarkable genetic heterogeneity of multiple myeloma poses a substantial challenge for proper prognostication and clinical management of patients. Here, we introduce MM-PSN, the
Abstract Among mammals, placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (for example, humans) are more vulnerable to malignancy. To
The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Project published 23 papers today (February 5), including several in Nature, with insights from the genomes of more
A group of genome researchers is making the case for sequencing the genomes of all eukaryotic species within ten years, predicting that it would benefit
On a sunny day near Perth, Australia, two-year-old Scarlett Whitmore stares intently at her left shoulder. With absolute concentration, she raises her head to look
Multiple myeloma (MM) is a biologically heterogeneous malignancy, however, the mechanisms underlying this complexity are incompletely understood. We report an analysis of the whole-genome sequencing
Summary By sequencing and comparing hundreds of bacterial genomes, researchers have shown that all of the explosive epidemics of cholera in Africa and the Americas
Summary By sequencing and comparing hundreds of bacterial genomes, researchers have shown that all of the explosive epidemics of cholera in Africa and the Americas
From the dry valleys of Antarctica to the depths of a Welsh coal mine, a promised revolution in genome sequencing may finally be catching fire.
When is a mutation a true genetic variant? Large-scale sequencing studies have set out to determine the low-frequency pathogenic genetic variants in individuals and populations.
Near Eastern genomes from Iran The genetic composition of populations in Europe changed during the Neolithic transition from hunting and gathering to farming. To better
Normal skin, which is often exposed to ultraviolet (UV) light throughout a person’s life, contains many potential disease-causing mutations clustered within a narrow range of
The small genome of the carnivorous, aquatic bladderwort packs a gene-rich punch that provides the unique plant with many of its special adaptations, according to
The American Journal of Human Genetics, Volume 89, Issue 1, p162, 15 July 2011. Carles Vilariño-Güell, Christian Wider, Owen A. Ross, Justus C. Dachsel et
The American Journal of Human Genetics, Volume 89, Issue 1, p162, 15 July 2011. Carles Vilariño-Güell, Christian Wider, Owen A. Ross, Justus C. Dachsel et
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