Abstract Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of patients with metastatic cSCC is poor emphasizing the need
Modeling TGF-β signaling in human skin Studies in mice and human tumors have identified multiple roles for TGF-β signaling in normal skin biology and in
Abstract The Hedgehog (Hh) cascade is central to development, tissue homeostasis and cancer. A pivotal step in Hh signal transduction is the activation of glioma-associated
Large studies have shown that taller people are more likely to develop cancer than shorter people. Until now, it’s been unclear whether the increased risk
A strain of Staphylococcus epidermis found on human skin contains a chemical with cancer-fighting abilities, according to a study published yesterday (February 28) in Science
Antioxidants decrease the levels of DNA-damaging, cancer-causing reactive oxygen species (ROS) that are formed during normal metabolism. Yet clinical trials that evaluated the health benefits
Normal skin, which is often exposed to ultraviolet (UV) light throughout a person’s life, contains many potential disease-causing mutations clustered within a narrow range of
In 1971, Angelo Lamola—who was then at Bell Laboratories—used an unusual chemical, trimethyldioxetane, to produce DNA lesions in a test tube. Decades later, the same
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