Highlights •Lung organoids express ACE2/TMPRSS2 and are permissive to SARS-CoV-2 infection •SARS-CoV-2 induces IFNs and cytokines/chemokines, and activates inflammasome pathway •SARS-CoV-2 infection in neurons activates
The first single-cell analysis of the human ovarian cortex revealed six main types of cells, but none of the oogonial stem cells that other researchers
Cell therapies to treat cardiac damage have been moving through clinical trials, with mixed results. Often, stem cells are taken from a patient’s bone marrow
Injections of stem cells—either a patient’s own or from a donor—into the hearts of people with cardiac conditions has been shown in some cases to
Scientists are experimenting with ways to selectively target the body’s blood-making cells for destruction. Early studies in animals and people suggest that the approach could
Since 2006, when Shinya Yamanaka, now the director of the Center for iPS Cell Research and Application at Kyoto University, discovered a method that could
Pelizaeus-Merzbacher disease is a genetic malady that leaves neurons without their myelin coating. This deficit has devastating consequences for the boys—it’s X-linked—who have it. “These
A single type of mouse stem cell can generate a structure in culture capable of self-organizing to generate both embryonic cells and those that are
An international team of researchers has created embryos containing both human and monkey cells, the Spanish newspaper El País reported July 31. The controversial project
Using human embryonic stem cells (ES cells), researchers have generated models of early human embryos in the lab that are more complex than any previous
The Japanese government’s health ministry has given the go-ahead for a trial of human induced pluripotent stem cells to treat spinal cord injury, Reuters reports
Neurons derived from the skin cells of people with and without autism spectrum disorder exhibit different patterns of growth and development, according to a study
For the first time, researchers have used the DNA from two mouse mothers to create healthy pups, some of which matured and had their own
The restoration of dentine lost in deep caries lesions in teeth is a routine and common treatment that involves the use of inorganic cements based
The outlook for patients with multiple myeloma has improved dramatically during the past two decades. The median overall survival is now more than 6 years,
How to maintain hematopoietic stem cells Hematopoiesis provides the body with a continuous supply of blood cells (see the Perspective by Sommerkamp and Trumpp). Taya
Many tissues harbor a reservoir of stem cells that remains quiescent but can be activated as needed for growth and repair. How cells enter, maintain,
Cells read their environment to trigger an appropriate response for tissue homeostasis. Work now shows that intestinal progenitor cells use the RNA-binding protein Lin-28 to
Chinese stem-cell scientists have welcomed long-awaited measures that, state media claim, will rein in rogue use of stem cells in clinics while allowing research. The
Scientists in Korea have injected human embryonic stem cell (hESC)-derived retinal support cells into the eyes of four men with macular degeneration, according to a
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