Highlights Summary Neural stem cells (NSCs) must exit quiescence to produce neurons; however, our understanding of this process remains constrained by the technical limitations of
Editor’s summary Idiopathic pulmonary fibrosis is characterized by failed lung regeneration and fibrosis development, ultimately leading to respiratory failure and death. Here, Lang and colleagues
Abstract Aging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and rapidly fatal interstitial lung disease marked by the replacement of lung alveoli with dense fibrotic
Highlights Summary Remote tumors disrupt the bone marrow (BM) ecosystem (BME), eliciting the overproduction of BM-derived immunosuppressive cells. However, the underlying mechanisms remain poorly understood.
Highlights Young HSCs traffic misfolded proteins to aggresomes in a Bag3-dependent manner High levels of autophagy maintain HSC proteostasis by degrading protein aggregates Bag3−/− HSCs have
Abstract Cellular metabolism is important for adult neural stem/progenitor cell (NSPC) behavior. However, its role in the transition from quiescence to proliferation is not fully
Abstract Tissue injury to skin diminishes miR-200b in dermal fibroblasts. Fibroblasts are widely reported to directly reprogram into endothelial-like cells and we hypothesized that miR-200b
Abstract Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1
Abstract V3 spinal interneurons are a key element of the spinal circuits, which control motor function. However, to date, there are no effective ways of
Abstract Haematopoietic ageing is marked by a loss of regenerative capacity and skewed differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production. Signals
Abstract Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a number of systemic hormones and transcription factors are known
Abstract While pluripotent stem cell-derived kidney organoids are now being used to model renal disease, the proximal nephron remains immature with limited evidence for key
Highlights Summary Although adult pluripotent stem cells (aPSCs) are found in many animal lineages, mechanisms for their formation during embryogenesis are unknown. Here, we leveraged Hofstenia
Abstract Squamous cell carcinomas are triggered by marked elevation of RAS–MAPK signalling and progression from benign papilloma to invasive malignancy1,2,3,4. At tumour–stromal interfaces, a subset
Time for T cell renewal Autologous hematopoietic stem cell transplantation (aHSCT) has shown great potential in subjects with multiple sclerosis (MS). Previous work showed a
Significance The main finding reported here is that acetylation converts superoxide dismutase-2 (SOD2) from a mitochondrial antioxidant to a nuclear histone demethylase. The change in
Highlights •In vivo multimodal imaging identified early signs of transplant rejection •Systemic immunosuppression was necessary for long-term survival of xenotransplants •Human donor photoreceptors integrated and differentiated mostly
Abstract Fetal exposure to gestational diabetes mellitus (GDM) predisposes children to future health complications including type-2 diabetes mellitus, hypertension, and cardiovascular disease. A key mechanism
Abstract In pursuit of treating Parkinson’s disease with cell replacement therapy, differentiated induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA)
Abstract Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber analysis to investigate how
Highlights • ZGA genes and transposable elements are expressed in 8CLCs but not in naive stem cells• DUX4 overexpression and spliceosome inhibition induce ZGA-like transcription•
Highlights •A single-cell resolution atlas of human adenomas and serrated polyps •Serrated polyps arise from metaplasia as opposed to stem cell expansion •Cytotoxic immunity in
Abstract Differentiation proceeds along a continuum of increasingly fate-restricted intermediates, referred to as canalization1,2. Canalization is essential for stabilizing cell fate, but the mechanisms that
Highlights •A single-cell resolution atlas of human adenomas and serrated polyps •Serrated polyps arise from metaplasia as opposed to stem cell expansion •Cytotoxic immunity in
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