Editor’s summary Cancer survivors often experience cognitive impairments after chemotherapy, and these side effects are commonly known as chemobrain. Here, Liu and colleagues treated breast
Abstract The pan-HER tyrosine kinase inhibitor (TKI) neratinib is therapeutically active against metastatic breast cancers harboring activating HER2 mutations, but responses are variable and often
Abstract Adoptive cell therapy (ACT) has proven to be highly effective in treating blood cancers, but traditional approaches to ACT are poorly effective in treating
Abstract Lysine L-lactylation [K(L-la)] is a newly discovered histone mark stimulated under conditions of high glycolysis, such as the Warburg effect. K(L-la) is associated with
Highlights •In a retrospective study, ex vivo drug testing predicts GBM patient survival •Testing is based on detecting subtle changes in single-cell mass •Predictive power of functional testing
Over the past few months, a number of drugs have been under investigation to treat COVID-19 without well-established safety or data to support these claims.
In efforts to identify a potential therapeutic strategy for COVID-19, Sumit Chanda, Ph.D., director and professor of the Immunity and Pathogenesis Program at Sanford Burnham Prebys Medical
In an animal model of multiple sclerosis (MS), decreasing the amount of a protein made in the liver significantly protected against development of the disease’s
Abstract Background Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the
Blasco et al. show that ablation of Egfr and Raf1 results in complete regression of a subset of mutant Kras/Trp53-induced pancreatic ductal adenocarcinomas (PDAC) without
Long-acting medicines have proved as effective as daily pills in preventing HIV from replicating, according to results from twin trials that enrolled more than 1,000
One of the major challenges of the current Zika virus (ZIKV) epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant
Highlights •A prospective trial reveals molecular actions of anti-PD-1 therapy •Anti-PD-1 therapy induces changes in the mutational burden of tumors •Distinct changes in gene expression
Gut microbes possibly influence not only the development of many human diseases, but also how these diseases respond to treatment. In tumor models, for example,
The development of oral insulin-sensitizing agents to minimize the need for injectable insulin remains a major unmet need in the treatment of diabetes. Now, writing
Therapies using T cells that are programmed to express chimeric antigen receptors (CAR T cells) consistently produce positive results in patients with hematologic malignancies. However,
Cancer cells have an unnatural appetite for certain amino acids—nonessential amino acids that healthy cells produce themselves, usually in amounts sufficient for ordinary metabolism. If
The outlook for patients with multiple myeloma has improved dramatically during the past two decades. The median overall survival is now more than 6 years,
Several factors have been identified that could be responsible for the collapse of honeybee populations. However, Raymann et al. have identified an antibiotic that appears
The creative minds at MIT have just devised a new strategy to target and abolish cancerous tumors. In the new study—published recently in Nature Communications
In 2015, 17 million HIV-infected individuals worldwide were on antiretroviral drug therapies, which are remarkably effective in suppressing the virus. Yet, 6000 people a day
The substitution of valine for glutamic acid in the β-chain of hemoglobin S (HbS) is associated with the formation of hemoglobin polymers that promote vaso-occlusion,
Highlights • Fasting mimicking diet induces prenatal-development gene expression in adult pancreas • FMD promotes Ngn3 expression to generate insulin-producing β cells • Cycles of
Neural stem cells (NSCs) are ideal recruits for search-and-destroy missions in the brain. They have an innate ability to home in on cancer cells, and
Left main coronary artery disease is associated with high morbidity and mortality owing to the large amount of myocardium at risk. European and U.S. guidelines
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