Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation
Abstract A distinct profile of NRAS mutants is observed in each tumor type. It is unclear whether these profiles are determined by mutagenic events or
Abstract A distinct profile of NRAS mutants is observed in each tumor type. It is unclear whether these profiles are determined by mutagenic events or
When Pol II meets nucleosome Eukaryotic cells organize their large genomes into a compacted structure called chromatin. The condensed structure of chromatin, with its fundamental
First off the COVID block The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been characterized by waves of transmission initiated by new variants
How to make selenoproteins In all domains of life, the essential trace element selenium is incorporated into selenoproteins as the amino acid selenocysteine during protein
Summary Background Tuberculosis remains a leading cause of global mortality, especially for adults and children living with HIV (CLHIV) underdiagnosed by sputum-based assays. Non-sputum-based assays
Significance Genome-wide association studies have identified two major risk loci for age-related macular degeneration (AMD) on chromosome (Chr) 1 and Chr10. Here, we use proteomics
Abstract RNA G-quadruplex (rG4)-SELEX is a method that generates L-RNA aptamers to target an rG4 structure of interest, which can be applied to inhibit G-quadruplex-mediated interactions
Gene interactions and global fitness The effect of a particular mutation in a given environment often varies systematically with the fitness of the genetic background
Cartography of human cells The function of disease genes active in different cell types is modulated to meet the needs of the different tissues and
Abstract Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As existing genome-wide association studies (GWAS) have been conducted predominantly in individuals of European descent,
Abstract Although circumstantial evidence supports enhanced Toll-like receptor 7 (TLR7) signalling as a mechanism of human systemic autoimmune disease1,2,3,4,5,6,7, evidence of lupus-causing TLR7 gene variants is lacking. Here
Abstract Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel
Abstract Cap-adjacent nucleotides of animal, protist and viral mRNAs can be O-methylated at the 2‘ position of the ribose (cOMe). The functions of cOMe in animals,
Abstract Heteroplasmic mitochondrial DNA (mtDNA) mutations are a common cause of inherited disease, but a few recurrent mutations account for the vast majority of new
Significance Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which can lead to respiratory failure. To date,
Abstract Maternal morbidity and mortality continue to rise, and pre-eclampsia is a major driver of this burden1. Yet the ability to assess underlying pathophysiology before
Abstract Background Research on the electroencephalographic (EEG) signatures of attention-deficit hyperactivity disorder (ADHD) has historically concentrated on its frequency spectrum or event-related evoked potentials. In
Highlights •Gene expression initiates at the one-cell stage in human embryos •Expression is of low magnitude but remains elevated until the eight-cell stage •Upregulated transcripts
Abstract High-throughput sequencing projects generate genome-scale sequence data for species-level phylogenies1–3. However, state-of-the-art Bayesian methods for inferring timetrees are computationally limited to small datasets and
Abstract Misfolding and aggregation of alpha-synuclein (αS) within dopaminergic neurons is a key factor in the development and progression of a group of age-related neurodegenerative
Abstract To evaluate the influence AMD risk genomic variants have on macular thickness in the normal population. UK Biobank participants with no significant ocular history
Abstract The remarkable genetic heterogeneity of multiple myeloma poses a substantial challenge for proper prognostication and clinical management of patients. Here, we introduce MM-PSN, the
Abstract Proteins are the primary effectors of function in biology, and thus, complete knowledge of their structure and properties is fundamental to deciphering function in
Abstract Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused on RT-PCR1. Host epigenome manipulation post coronavirus infection2,3,4 suggests that DNA methylation
Highlights •Identification of cohesin’s DNA binding sites and movements needed for loop extrusion •A DNA binding site on the hinge might translocate DNA by ATP-independent
Created by ePubSystems. Contact Us for similar site for your university or institute.