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Engineered Protein Blocks Cancer Growth and Regenerates Neurons
Ligands are protein molecules that transmit signals in between or within the cells. They exert their effects by binding to cellular proteins called receptors. After
Ligands are protein molecules that transmit signals in between or within the cells. They exert their effects by binding to cellular proteins called receptors. After
Abstract In biological systems, the activities of macromolecular complexes must sometimes be turned off. Thus, a wide variety of protein inhibitors has evolved for this
Abstract Doxorubicin, the most prescribed chemotherapeutic drug, causes dose-dependent cardiotoxicity and heart failure. However, our understanding of the immune response elicited by doxorubicin is limited.
Abstract An influenza vaccine approach that overcomes the problem of viral sequence diversity and provides long-lived heterosubtypic protection is urgently needed to protect against pandemic
Abstract Many biological systems exhibit precise timing of events, and one of the most known examples is cell lysis, which is a process of breaking
Abstract Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of insulin. To explore how the Ca2+ response is orchestrated in space and
Abstract 5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. In eukaryotes, 5mC has gained complex roles in gene regulation beyond parasite control,
Editor’s summary Commonly used T cell therapies such as engineered T cell receptors (TCRs) and chimeric antigen receptors (CARs) have greatly improved outcomes for many
Abstract Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by pathological T cell–B cell interactions1,2. Expansion of T follicular helper (TFH) and T peripheral
bstract The expression of tumor-specific antigens during cancer progression can trigger an immune response against the tumor. Here, we investigate if microproteins encoded by noncanonical
Editor’s summary Mutations in MIR96, a microRNA expressed in inner hair cells, result in autosomal dominant deafness-50 (DFNA50), a form of nonsyndromic hearing loss. Here, Zhu et
Abstract Prime editing (PE) enables precise and versatile genome editing without requiring double-stranded DNA breaks. Here we describe the systematic optimization of PE systems to
Highlights Summary Sensory perception is dynamic, quickly adapting to sudden shifts in environmental or behavioral context. Although decades of work have established that these dynamics
Abstract Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin-stained tumor slides for precision oncology. We present ENLIGHT–DeepPT, an indirect two-step
Editor’s summary Respiratory diseases caused by different infectious agents can look similar and can rely on similar therapeutic approaches to dampen inflammation. Here, Shepard et al. identified
Highlights Summary The currently accepted intestinal epithelial cell organization model proposes that Lgr5+ crypt-base columnar (CBC) cells represent the sole intestinal stem cell (ISC) compartment. However,
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour
Abstract To maximize the impact of precision medicine approaches, it is critical to identify genetic variants underlying disease and to accurately quantify their functional effects.
Abstract Brain computation performed by billions of nerve cells relies on a sufficient and uninterrupted nutrient and oxygen supply1,2. Astrocytes, the ubiquitous glial neighbours of
Editor’s summary Regulating cytokine activity can effectively manage inflammatory bowel disease, but traditional treatments are immunosuppressant or only target specific cytokines. By combining the robust
Abstract Once considered as a “metabolic waste,” lactate is now recognized as a major fuel for tricarboxylic acid (TCA) cycle. Our metabolic flux analysis reveals
Highlights Summary Resistance to targeted therapy remains a major clinical challenge in melanoma. To uncover resistance mechanisms, we perform single-cell RNA sequencing on fine-needle aspirates
Editor’s summary Chemotherapy for acute myeloid leukemia (AML) can result in cardiotoxicity. Pan et al. found that the angiotensin II receptor type 1 (AGTR1) was increased in
Abstract The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies either on fed-batch and manual processes that often lack environmental monitoring and
Editor’s summary Cancer immunotherapy is a type of treatment that mobilizes a patient’s immune system to kill tumor cells. It has been successful in treating
The aging of the world’s population has intensified interest in understanding the aging process and devising strategies and interventions to prolong a healthy life span.
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