Ligands are protein molecules that transmit signals in between or within the cells. They exert their effects by binding to cellular proteins called receptors. After
Abstract Macrophages orchestrate tissue homeostasis and immunity. In the tumor microenvironment (TME), macrophage presence is largely associated with poor prognosis because of their reprogramming into
Highlights •Low-cost and rapid paper microfluidic device for on-site wastewater surveillance •Sensing platform for pandemic preparedness and public health •Field testing of SARS-CoV-2 in wastewater
Abstract Persistent colonization and outgrowth of potentially pathogenic organisms in the intestine can result from long-term antibiotic use or inflammatory conditions, and may perpetuate dysregulated immunity
Abstract Mutations in parkin and PINK1 cause early-onset Parkinson’s disease (EOPD). The ubiquitin ligase parkin is recruited to damaged mitochondria and activated by PINK1, a
Highlights •Binding of TOM1 VHS to ubiquitin is enhanced by an internal DXXLL motif •Binding of TOM1 to PtdIns5P is maximal under acidic conditions •TOLLIP’s
Highlights •An efficient pipeline to generate LoF alleles in hiPSC using DNA base editing •22 LoF alleles of neuropsychiatric risk genes were generated on 3
Abstract Treatment of Parkinson’s disease (PD) is based on the use of dopaminergic drugs, such as L-Dopa and dopamine receptor agonists. These substances counteract motor
Abstract Cells establish the asymmetrical distribution of phospholipids and alter their distribution by phospholipid scrambling (PLS) to adapt to environmental changes. Here, we demonstrate that
Abstract Trastuzumab deruxtecan (T-DXd) intracranial activity has been observed in small or retrospective patient cohorts with human epidermal growth factor receptor 2–positive (HER2+) advanced/metastatic breast
Abstract Androgen deprivation therapy (ADT) for prostate cancer is associated with an increased risk of dementia, including Alzheimer’s disease (AD). The mechanistic connection between ADT
Abstract XPO1 (Exportin-1/CRM1) is a nuclear export protein that is frequently overexpressed in cancer and functions as a driver of oncogenesis. Currently small molecules that
Highlights • Apo DdmD assembles as an autoinhibited dimer for plasmid nicking • DdmE is a DNA-guided, DNA-targeting Argonaute-like protein and prefers short guides •
Abstract Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many
Highlights • Proteo-metabolomics predicts SDS dependency that is validated in patient tumor slices • OAT, GLS, and ALDH18A1 form an axis central to mitochondrial rewiring
Significance Since metabolic dysfunction-associated steatohepatitis (MASH) is the most common liver disease in the United States, the mechanisms underlying its regression are key to developing
Abstract For over a century, fasting regimens have improved health, lifespan and tissue regeneration in diverse organisms, including humans1,2,3,4,5,6. However, how fasting and post-fast refeeding
Editor’s summary Alzheimer’s disease has been associated with brain metabolic alterations. Minhas et al. studied the role of glucose metabolism impairments on disease progression using a
Significance Synchronization between cells plays a critical role in cell-to-cell communication. Although electrical and chemical communications were studied, mechanical communication is recently recognized as a
Highlights Summary Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness
Editor’s summary Vancomycin and its second-generation lipoglycopeptide derivatives work mainly by binding the peptidoglycan precursor lipid II to inhibit cell wall synthesis in Gram-positive bacteria.
Editor’s summary During replication, RNA viruses frequently generate defective particles that parasitize and interfere with the replication and packaging of intact virus. Such defective particles
Abstract Episodic memory in older adults is varied and perceived to rely on numbers of synapses or dendritic spines. We analyzed 2157 neurons among 128
Abstract We present a bioprinted three-layered airway model with a physiologically relevant microstructure for the study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection dynamics. This
Highlights Summary Caspase recruitment domain family member 14 (CARD14) and its variants are associated with both atopic dermatitis (AD) and psoriasis, but their mechanistic impact
Abstract Sickle cell disease is a growing health burden afflicting millions around the world. Clinical observation and laboratory studies have shown that the severity of
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