Molecular Medicine Israel

Making Sense of the Tumor Exome

An algorithm can pick out biologically and clinically meaningful variants from whole-exome sequences of tumors

In the march toward personalized medicine, genotyping cancers has become more and more complex. Panels that pick up variations in hundreds of potentially important genes can help physicians determine how a particular tumor operates and the best course of treatment. Whole-exome sequencing—the analysis of all the coding regions of the genome—has been somewhat of a pipe dream for clinical oncology, but a study published on May 19 in Nature Medicine introduces a platform for analyzing the entire exome of cancer patients’ tumors…

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