In the march toward personalized medicine, genotyping cancers has become more and more complex. Panels that pick up variations in hundreds of potentially important genes can help physicians determine how a particular tumor operates and the best course of treatment. Whole-exome sequencing—the analysis of all the coding regions of the genome—has been somewhat of a pipe dream for clinical oncology, but a study published on May 19 in Nature Medicine introduces a platform for analyzing the entire exome of cancer patients’ tumors…