Serotonergic activity is dysregulated in depression and anxiety disorders, but less is known about the role of microRNAs (miRNAs) in mood disorders. miR-135, which inhibits expression of the serotonin transporter and inhibitory serotonin autoreceptor, was upregulated in serotonin neurons of animals that were treated with antidepressants. Mice that overexpressed miR-135…