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Editor’s summary Mutations in MIR96, a microRNA expressed in inner hair cells, result in autosomal dominant deafness-50 (DFNA50), a form of nonsyndromic hearing loss. Here, Zhu et
Abstract Prime editing (PE) enables precise and versatile genome editing without requiring double-stranded DNA breaks. Here we describe the systematic optimization of PE systems to
Highlights Summary Sensory perception is dynamic, quickly adapting to sudden shifts in environmental or behavioral context. Although decades of work have established that these dynamics
Abstract Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin-stained tumor slides for precision oncology. We present ENLIGHT–DeepPT, an indirect two-step
Editor’s summary Respiratory diseases caused by different infectious agents can look similar and can rely on similar therapeutic approaches to dampen inflammation. Here, Shepard et al. identified
Highlights Summary The currently accepted intestinal epithelial cell organization model proposes that Lgr5+ crypt-base columnar (CBC) cells represent the sole intestinal stem cell (ISC) compartment. However,
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour
Abstract To maximize the impact of precision medicine approaches, it is critical to identify genetic variants underlying disease and to accurately quantify their functional effects.
Abstract Brain computation performed by billions of nerve cells relies on a sufficient and uninterrupted nutrient and oxygen supply1,2. Astrocytes, the ubiquitous glial neighbours of
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