Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes to the PDAC tumour
Significance While rapalogs have been thought to function primarily by suppressing mTORC1 in kidney cancer cells, we show that mTORC1 inhibition of nontumor cells is
Highlights Summary Resistance to MAPK inhibitors (MAPKi), the main cause of relapse in BRAF-mutant melanoma, is associated with the production of alternative BRAF mRNA isoforms (altBRAFs)
Abstract Acquired platinum resistance poses a significant therapeutic impediment to ovarian cancer patient care, accounting for more than 200,000 deaths annually worldwide. We previously identified
Abstract HIV-1 infection depends on the integration of viral DNA into host chromatin. Integration is mediated by the viral enzyme integrase and is blocked by
Summary Microhomology-mediated end joining (MMEJ) is an intrinsically mutagenic pathway of DNA double-strand break (DSB) repair essential for proliferation of homologous recombination (HR)-deficient tumors. Although targeting MMEJ
Abstract A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply elemental
Highlights •Covalent K-Ras(G12C) inhibitors give rise to chemically modified cancer neoepitopes •Antibodies against these neoepitopes are identified by phage display •Bispecific antibodies induce T cell-mediated killing
Abstract The pan-HER tyrosine kinase inhibitor (TKI) neratinib is therapeutically active against metastatic breast cancers harboring activating HER2 mutations, but responses are variable and often
Panning for antibiotics that stand out Despite their importance in modern medicine, antibiotics are under constant threat as pathogens adapt, acquire, or evolve resistance with
Abstract Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ
T argeted therapy and immunotherapy are often employed as a one-two punch to treat certain cancers, but sometimes this approach falls short. In a study
Despite the recent progress made in treating melanoma, an ongoing issue is the development of drug resistance to promising target-specific therapeutic strategies, resulting in treatment
Significance mTOR plays a critical role in regulating cell growth and is an important anticancer target. Numerous studies using mTOR inhibitors have shown that mTOR
Researchers in Korea say they have developed an anticancer drug that could potentially prevent drug resistance. The scientists, from the Korea Institute of Science and
A novel drug based on a natural compound found in broccoli, kale and other cruciferous vegetables could hold the key to reversing or even preventing
The identification of artemisinin (ART) in 1971 allowed treatment of malaria resistant to chloroquine, the prevailing drug at the time, and provided hope for a
About half a million people, most of them children living in Africa, are killed each year by malaria1. Management of malaria, particularly that caused by
An antiflu medication first approved in Japan in 2018 and given the green light later that year in the US may be fostering the emergence
In response to antibiotic treatment, bacteria improve their odds of survival by increasing the rate of mutations in their genomes, giving them more chances to
A treatment regimen for extensively drug-resistant tuberculosis could help stem the growing problem of hard-to-treat TB infections in developing countries, according to the Associated Press.
The US Food and Drug Administration issued a safety alert for fecal transplant procedures after two immune-compromised patients contracted drug-resistant infections, according to a statement
Plasmodium falciparum resistance to artemisinin-based combination therapies (ACTs) started to crop up around 2007. Infections, especially in the Greater Mekong area of Southeast Asia, seemingly
EDITOR’S CHOICE IN ONCOLOGY THE PAPER C. Ambrogio et al., “KRAS dimerization impacts MEK inhibitor sensitivity and oncogenic activity of mutant KRAS,” Cell, 172:857-68.e15, 2018.
Antibiotics are known to influence the growth of bacteria in the human body. But new research led by a team at the European Molecular Biology
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