Abstract Immunotherapy based on immunecheckpoint blockade (ICB) using antibodies induces rejection of tumours and brings clinical benefit in patients with various cancer types1. However, tumours
Abstract Background: A causal relationship between statin use and intracerebral hemorrhage (ICH) is uncertain. We hypothesized that an association between long-term statin exposure and ICH risk
Abstract Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria
Abstract Phenotype-based compound screening has advantages over target-based drug discovery, but is unscalable and lacks understanding of mechanism of drug action. A chemical-induced gene expression
The development of resistance to cancer therapy is a major predictor of patient mortality. Therefore, understanding resistance mechanisms is key to improving therapeutic outcomes. Writing
At the annual American Society of Clinical Oncology meeting last June, Bristol-Myers Squibb (BMS) researchers presented data on a cohort of patients not responding to
At the annual American Society of Clinical Oncology meeting last June, Bristol-Myers Squibb (BMS) researchers presented data on a cohort of patients not responding to
For as long as there has been civilization, there have been mind-altering drugs. Alcohol has been around for at least 10,000 years, but recent advances
Cancer is a complex disease and a leading cause of death worldwide. Extensive research over decades has led to the development of therapies that target
Researchers report promising results in a Phase 1 trial testing a new cell therapy using chimeric antigen receptor (CAR) T-cell technology on patients suffering from
A new treatment strategy has had astonishing success against extensively drug-resistant tuberculosis (XDR TB), which kills more than 70% of patients. XDR and other drug-resistant
Over the past few decades, the number of deaths from cardiovascular disease has declined substantially in developed countries. Statins, drugs that lower serum levels of
It’s practically dogma at the health food store: Substances called antioxidants, found in foods from blueberries to broccoli, are cancer’s nemesis, and the more you
If Patient X were like most people with advanced bladder cancer, she would probably be dead by now. After her first diagnosis, she received standard
If Patient X were like most people with advanced bladder cancer, she would probably be dead by now. After her first diagnosis, she received standard
If Patient X were like most people with advanced bladder cancer, she would probably be dead by now. After her first diagnosis, she received standard
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