Abstract The analysis of cell-free DNA (cfDNA) in plasma provides information on pathological processes in the body. Blood cfDNA is in the form of nucleosomes,
Highlights •Transmission of PCOS traits in mice occurs via an altered DNA methylation landscape •Metabolic- and inflammatory-related pathways are dysregulated in models of PCOS •Common
Although neurobiologist Oded Rechavi comes from a family of doctors and researchers, it was not his original plan to go into science. “It wasn’t something
Every man, woman, and mouse partakes in a different amount of voluntary physical activity. Some willingly run miles a day with no destination in mind,
Current genetic testing methods often fall short in diagnosing pediatric patients with developmental delay, intellectual disability, or congenital abnormalities. Sometimes, this is because certain genetic
DNA methylation status in a variety of tissues can accurately reveal the age of an animal, but previously discovered epigenetic clocks often aren’t evolutionarily conserved.
•PRMT6 is downregulated in HCC and correlates negatively with aggressive HCC •PRMT6 silencing drives cancer stemness in vitro and patient-derived organoids •PRMT6 binds to CRAF,
Chemical groups tacked onto DNA or histone proteins regulate how and when genes are expressed. Environmental signals can change the placement of these epigenetic tags,
Last May, to much fanfare, an international group of researchers published two papers describing a new in vitro system that had maintained human embryos in
For years, neurons in the brain were assumed to all carry the same genome, with differences in cell type stemming from epigenetic, transcriptional, and posttranscriptional
One day in 2006, while a postdoc in the Rockefeller University laboratory of Nathaniel Heintz, I had an unexpected eye-opener. Heintz showed me some electron
When a virus invades a host cell, it needs to do some remodeling to make the environment safe for itself. In recent years, researchers have
Highlights •Stem cell lineage infidelity occurs transiently in wounds and persists in cancer •Wounds and cancer converge on lineage infidelity irrespective of stem cell origin
Scientists at Dartmouth’s Norris Cotton Cancer Center (NCCC) say they have identified the functional role of two distinct DNA modifications in glioblastoma (GBM) tissues. The
In cells undergoing senescence, chromosomes tend to become more compact, according to a report published today (February 5) in Science Advances.This and other chromatin rearrangements
A team led by researchers from the University of Copenhagen discovered differences in the sperm epigenomes of lean and obese men, and in the sperm
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