Abstract Chromatin modifications are linked with regulating patterns of gene expression, but their causal role and context-dependent impact on transcription remains unresolved. Here we develop
Abstract Tissues within an organism and even cell types within a tissue can age with different velocities. However, it is unclear whether cells of one
Abstract Cells undergo a major epigenome reconfiguration when reprogrammed to human induced pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human
Two new studies have characterized the genome-scale landscapes of DNA methylation in human early embryos. Although the broad principles of how the epigenome is reprogrammed
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