Abstract The expansion of the neocortex, a hallmark of mammalian evolution1,2, was accompanied by an increase in cerebellar neuron numbers3. However, little is known about
Retroviral origins of antiviral proteins Sequences of retroviral origins are abundant in the human genome, but their functional significance remains poorly understood. Frank et al. identified
Abstract High-throughput sequencing projects generate genome-scale sequence data for species-level phylogenies1–3. However, state-of-the-art Bayesian methods for inferring timetrees are computationally limited to small datasets and
When COVID-19 spread around the globe this year, David Montefiori wondered how the deadly virus behind the pandemic might be changing as it passed from
How a cancer evolves and how mutations are generated are highly intertwined processes, and both are nearly impossible to observe directly. Instead, we are usually
From Alaska down to the Baja Peninsula, the rocky tide pools of North America’s West Coast are separated by hundreds of kilometers of sandy beaches.
Koalas are susceptible to cancers such as lymphoma and leukemia along with chlamydia infections due to koala retrovirus, a pathogen that began inserting itself into
Scientists extracted a near-complete HIV-1 genome from a lymph node that had been preserved in wax for more than 50 years. The sample stands as
There should be a global moratorium on editing heritable DNA from humans, scientists and bioethicists from seven countries write today (March 13) in a Nature
The paper I. Turgeman-Grott et al., “Pervasive acquisition of CRISPR memory driven by inter-species mating of archaea can limit gene transfer and influence speciation,” Nat
The great white shark genome—like the animal itself—is giant, with 41 pairs of chromosomes compared to humans’ 23 pairs, researchers reported yesterday (January 18) in
The DNA of life on Earth naturally stores its information in just four key chemicals — guanine, cytosine, adenine and thymine, commonly referred to as
DNA methylation status in a variety of tissues can accurately reveal the age of an animal, but previously discovered epigenetic clocks often aren’t evolutionarily conserved.
Large studies have shown that taller people are more likely to develop cancer than shorter people. Until now, it’s been unclear whether the increased risk
This year’s Nobel Prize in Chemistry was awarded to three scientists who harnessed evolution in the lab. Frances Arnold, a chemical engineer at the California
When Homo sapiens crossed paths with their Neanderthal cousins tens of thousands of years ago in Europe, they also encountered dangerous new pathogens—and, though interbreeding,
Researchers in Portugal studying a rare type of hybrid fish in the Ocreza River have found an individual that is the exact genomic match to
Evolutionarily speaking, we are born to make babies. Our bodies and brains don’t fall apart until we come to the end of our child-bearing years.
Since its discovery in Africa in the 1950s, chikungunya virus has traveled around the Indian Ocean region, infecting tens of millions of people. Those affected
Nature 480, 250–253 ( 2011) ; DOI: 10.1038/nature10665 Alejandro Burga, M. Olivia Casanueva, Ben Lehner. “Predicting mutation outcome from early stochastic variation in genetic interaction
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