![](https://www.molecular-medicine-israel.co.il/wp-content/uploads/2014/11/fda-164.png)
Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death
Highlights •Homozygous LoF TBK1 produces systemic autoinflammation, not overt viral disease. •Expressed but inactive TBK1 inhibits IFN-I induction more than no TBK1. •Autoinflammation is driven