Abstract Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular biological mechanisms remains challenging due to the
Editor’s summary Microbial biochemicals systems are incredibly diverse, and computational tools to analyze sequence data are essential in identifying new and valuable components for biotechnology
Abstract The ever-growing compendium of genetic variants associated with human pathologies demands new methods to study genotype–phenotype relationships in complex tissues in a high-throughput manner1,2.
Abstract MicroRNAs (miRNAs) exert their gene regulatory effects on numerous biological processes based on their selection of target transcripts. Current experimental methods available to identify
Abstract Neural crest cells (NCCs) give rise to various tissues including neurons, pigment cells, bone and cartilage in the head. Distal-less homeobox 5 (Dlx5) is involved in
Identifying transcript location in cells Identifying where specific RNAs occur within a cell or tissue has been limited by technology and imaging capabilities. Expansion microscopy
Radiotherapy is a cornerstone of today’s cancer treatment. About half of all people suffering from cancer with a so-called radiotherapy. For this, patients are usually
Introns are short stretches of non-coding DNA interspersed with the coding DNA in the genes of eukaryotic organisms. They are widespread and common but their
The influenza virus mutates constantly, and work1 published this month on bioRxiv reveals that this viral volatility can affect whether, and how, a host cell
Summary Hundreds of genes influence how tall a person is, but most make an imperceptible difference—perhaps a millimeter, for example. Now, a group studying the
Highlights High-throughput DNA sequencing, including whole-genome and -exome sequencing, has proven a successful strategy for gene identification in ALS. Substantial progress in gene identification revealed
A very focused function for lncRNAs The human genome generates many thousands of long noncoding RNAs (lncRNAs). A very small number of lncRNAs have been
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