Abstract Coordination of cellular activity through Ca2+ enables β cells to secrete precise quantities of insulin. To explore how the Ca2+ response is orchestrated in space and
Highlights Summary Neurons require large amounts of energy, but whether they can perform glycolysis or require glycolysis to maintain energy remains unclear. Using metabolomics, we
Abstract Pancreatic islets control glucose homeostasis by the balanced secretion of insulin and other hormones, and their abnormal function causes diabetes or hypoglycaemia. Here we
Chemical groups tacked onto DNA or histone proteins regulate how and when genes are expressed. Environmental signals can change the placement of these epigenetic tags,
In the early 2000s, a long-standing problem affecting diabetes sufferers around the world seemed on the brink of being solved. After years of research and
Engineering cells to regulate glucose Diabetes mellitus affects hundreds of millions of people worldwide. Blood glucose levels are chronically deregulated in diabetics, and this can
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