Highlights Young HSCs traffic misfolded proteins to aggresomes in a Bag3-dependent manner High levels of autophagy maintain HSC proteostasis by degrading protein aggregates Bag3−/− HSCs have
Significance mTOR plays a critical role in regulating cell growth and is an important anticancer target. Numerous studies using mTOR inhibitors have shown that mTOR
Abstract Most of the hematopoietic stem cells (HSCs) within the bone marrow (BM) show quiescent state with a low mitochondrial membrane potential (ΔΨm). In contrast,
β-Thalassemia is a blood disease caused by mutations in the β-globin gene. β-Globin is a subunit of hemoglobin, an oxygen-carrying protein in red blood cells.
Stemming attacks on the pancreas In type 1 diabetes, autoreactive CD4 T cells attack and kill pancreatic β cells, disrupting insulin production. Many approaches have
Researchers have halted the progression of leukemia in mice by restoring the enzyme TET2 in hematopoietic stem cells, either by reestablishing its gene expression in
Two teams of scientists have generated blood stem cells by reprogramming either human or mouse cells. In both cases, these hematopoietic stem cells successfully produced
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