Abstract Lysine demethylase 5A (KDM5A) is a negative regulator of histone H3 lysine 4 trimethylation (H3K4me3), a histone mark associated with activate gene transcription. We
A central aspect of aging research concerns the question of when individuality in lifespan arises1. Here we show that a transient increase in reactive oxygen
Each human cell contains so much DNA — about 2 metres if extended — that it must be tightly wrapped around specialized histone proteins to
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