Editor’s summary Although current spatial transcriptomics technologies can locate gene expression within tissues, they are unable to map full-length B cell receptor (BCR) and T
Long-lived plasma cell production High-affinity antibodies that provide durable protective immunity are produced by long-lived bone marrow plasma cells that differentiate from germinal center (GC)
The Clinical Implications of Basic Research series has focused on highlighting laboratory research that could lead to advances in clinical therapeutics. However, the path between the laboratory
Ancestry shapes genetic immune responses Selection for genes affecting the immune system can vary among populations because of selection for local environments. In humans, ancestry
Psoriasis is a chronic autoimmune skin disease that speeds up the growth cycle of skin cells. It is the most common autoimmune disease in the
Early action of IgA Humoral immune responses play a critical role in protecting individuals against SARS-CoV-2 infection, particularly through the activity of neutralizing antibodies. Sterlin et
Resident help for fighting influenza Memory T cells take up residence in the lung after respiratory virus infection to facilitate rapid and localized immune responses
Our ability to keep HIV under control has been revolutionized by antiretroviral therapy (ART). But ART is not a cure — the HIV genome can
For some COVID-19 patients, the body’s immune response may be as destructive as the virus that causes the disease. The persistent high fevers, severe respiratory
In this issue of Cancer Cell, Liao et al. demonstrate that oncogenic KRAS drives an immune suppressive program in colorectal cancer by repressing IRF2 expression,
Previous studies have found that a warming climate may change the distribution of different diseases and the insects that carry them. Now, a new study
Ovarian cancer is a particularly hard-to-treat disease. It’s often diagnosed late, and even after surgery and chemotherapy, around 85 percent of patients relapse and develop
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