Two cancer patients were successfully treated with fecal microbiota transplants (FMTs) for colitis caused by immunotherapy, according to a case report published today (November 12)
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
The increasing frequency of antimicrobial resistance is a problem of global importance. Novel strategies are urgently needed to understand and inhibit antimicrobial resistance gene transmission
Takinib, a selective TAK1 inhibiting drug, has been shown to broaden the therapeutic efficacy of TNF-alpha (Tumor necrosis factor-alpha) inhibition for treating cancer and autoimmune
BACKGROUND Alectinib, a highly selective inhibitor of anaplastic lymphoma kinase (ALK), has shown systemic and central nervous system (CNS) efficacy in the treatment of ALK-positive
Summary Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA
Merck & Co. has won FDA approval for its melanoma immunotherapy Keytruda (pembrolizumab), formerly called MK-3475—the first programmed death receptor-1 (PD-1) inhibitor to be allowed for use as a
Merck & Co. has won FDA approval for its melanoma immunotherapy Keytruda (pembrolizumab), formerly called MK-3475—the first programmed death receptor-1 (PD-1) inhibitor to be allowed for use as a
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