Highlights •Altered mitochondrial homeostasis reprograms cell death modalities •Mitochondrial ROS directs GSDMD to mitochondria following inflammasome activation •Mito-GSDMD shifts cell death from pyroptosis to necroptosis
In addition to providing partial protection against pediatric tuberculosis, vaccination with bacille Calmette-Guérin (BCG) has been reported to confer nonspecific resistance to unrelated pulmonary pathogens,
Researchers at the University of Washington have discovered a novel DNA-sensing pathway that launches an antiviral response to foreign genetic material in human cells. Triggered
scientists have long believed that humans and many other mammals have two types of immune systems: innate and adaptive. The former is driven by natural
Highlights •Nitric oxide binds to the staphylococcal virulence regulator AgrA •S-nitrosylation of AgrA inhibits staphylococcal virulence •Nitric oxide is protective in a murine pneumonia model
Abstract The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family of cytidine deaminases plays an important role in the innate immune response to viral
The human genome is peppered with the DNA of extinct hominins—Neanderthals and Denisovans—as a result of interbreeding with early Homo sapiens. According to some reports,
Pregnant mice expose their unborn pups to maternal gut microbes, which can affect the development of the innate immune system after birth, according to a
Part of the innate immune system, white blood cells called neutrophils circulate in the blood and are the first responders to an influenza respiratory infection,
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