Abstract BACKGROUND In treatment-resistant depression, commonly defined as a lack of response to two or more consecutive treatments during the current depressive episode, the percentage
Highlights •Repeated ketamine anesthesia induces perineuronal net loss •PNN loss reinstates juvenile-like ocular dominance plasticity •Microglia interact with parvalbumin neurons and remodel PNN •60-Hz light
The anesthetic drug ketamine could be used to rewire heavy drinkers’ memories and help them cut down on alcohol consumption, according to a study published
Imaging of neurons in the brains of living mice reveals how synapses between cells are eliminated in response to stress and reinstated by an antidepressant
The anaesthetic drug ketamine also has a rapid antidepressant effect. Although ketamine is known to block N-methyl-D-aspartate (NMDA) receptors, its exact target—which brain region and
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