SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Highlights •SRPKIN-1 is the first irreversible inhibitor for SRPK1/2 kinase •SRPKIN-1 is the first kinase inhibitor that targets a tyrosine residue covalently •SRPKIN-1 inhibits phosphorylation
