Highlights • Proteo-metabolomics predicts SDS dependency that is validated in patient tumor slices • OAT, GLS, and ALDH18A1 form an axis central to mitochondrial rewiring
Abstract Immune checkpoint inhibitors targeting PD-1/L1 have modest efficacy in hepatocellular carcinoma as single agents. Targeting membranous phosphatidylserine may induce pro-inflammatory and -immune stimulating effects
Abstract Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T cell rich tumors fail to respond to
Abstract A potentially curative hepatic resection is the optimal treatment for hepatocellular carcinoma (HCC) but most patients are not candidates for resection and most resected
Abstract Elevated plasma levels of hyaluronic acid (HA) is a disease marker in liver pathology and other inflammatory disorders. Inhibition of HA synthesis with coumarin
Significance Phosphohistidine (pHis) is a labile posttranslational modification with two isoforms, 1-pHis and 3-pHis, involved in many cellular processes across the kingdoms of life. Due
RNA sequencing may help doctors diagnose hepatocellular carcinoma earlier, according to preliminary data presented Sunday (March 31) at the American Association for Cancer Research annual
Created by ePubSystems. Contact Us for similar site for your university or institute.