Editor’s summary Polycystic ovary syndrome is a common endocrine condition in women of reproductive age. Its manifestations include androgen excess and other hormonal changes, menstrual
Editor’s summary The malaria parasite has a complex life cycle that offers many potential targets for control measures. One of the most vulnerable points in
Abstract Malaria is a major cause of illness and death worldwide. Rapid diagnostic tests are the most widely used tool for detecting malaria infection, however, they only
Abstract Increasing levels of artemisinin and partner drug resistance threaten malaria control and elimination globally. Triple artemisinin-based combination therapies (TACTs) which combine artemisinin derivatives with
Abstract Malaria is caused by Plasmodium species transmitted by Anopheles mosquitoes. Following a mosquito bite, Plasmodium sporozoites migrate from skin to liver, where extensive replication occurs, emerging later as merozoites that
Abstract A highly effective malaria vaccine remains elusive despite decades of research. Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), a metabolically active, nonreplicating, whole parasite vaccine demonstrated safety
Multistage antimalarial Malaria is caused by infection with the protozoan parasite Plasmodium spp. and remains a serious global health threat. The emergence of resistance to existing antimalarial
A first-in-human Phase I clinical trial has found that one dose of a monoclonal antibody, designated CIS43LS, safely prevented malaria for up to nine months
Abstract The global decline in malaria has stalled1, emphasizing the need for vaccines that induce durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination
Abstract Malaria is caused by unicellular Plasmodium parasites. Plasmodium relies on diverse microtubule cytoskeletal structures for its reproduction, multiplication, and dissemination. Due to the small size of this parasite,
Abstract For some diseases, successful vaccines have been developed using a nonpathogenic counterpart of the causative microorganism of choice. The nonpathogenicity of the rodent Plasmodium berghei (Pb)
Abstract Background Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, and reported to be efficient in Chinese COV-19 patients. We evaluate the
The identification of artemisinin (ART) in 1971 allowed treatment of malaria resistant to chloroquine, the prevailing drug at the time, and provided hope for a
The number of malaria infections recorded globally has fallen for the first time in several years, according to the World Health Organization (WHO), which published
About half a million people, most of them children living in Africa, are killed each year by malaria1. Management of malaria, particularly that caused by
A program to vaccinate young children in high-risk areas for malaria begins today (April 23) in Malawi, and will soon roll out in Ghana and
Plasmodium falciparum resistance to artemisinin-based combination therapies (ACTs) started to crop up around 2007. Infections, especially in the Greater Mekong area of Southeast Asia, seemingly
The tenacity of the malaria parasite has all too often made it intractable to long-term therapeutic intervention. The development of parasite drug resistance is almost
nfection with the parasite Plasmodium falciparum causes malaria. Individuals may be infected with multiple strains of P. falciparum, some of which may be drug-resistant. Understanding
Some malaria researchers say their worst fears are coming true. A malaria parasite resistant to resistant to a first-line artemisinin combination therapy has rapidly made
During infection, malaria parasites must invade erythrocytes. Erythrocytes are flexible cells that can easily deform to make it through the tight spaces of the vasculature,
In 1927, Austrian physician Julius Wagner-Jauregg won the Nobel Prize in Physiology or Medicine for his discovery of the therapeutic value of malaria inoculation in
Artemisinin-based therapies are the only effective treatment for malaria, the most devastating disease in human history. To meet the growing demand for artemisinin and make
The malaria vaccine doesn’t provide lasting protection against the mosquito-borne disease, according to a study published yesterday (June 29) in NEJM: it delays infections by
Researchers have identified a gene that kickstarts the male-specific genetic program in the African malaria mosquito Anopheles gambiae. When expressed in genetically female mosquito embryos,
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