Highlights Summary Resistance to targeted therapy remains a major clinical challenge in melanoma. To uncover resistance mechanisms, we perform single-cell RNA sequencing on fine-needle aspirates
Highlights Summary Resistance to MAPK inhibitors (MAPKi), the main cause of relapse in BRAF-mutant melanoma, is associated with the production of alternative BRAF mRNA isoforms (altBRAFs)
Abstract Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The prognosis of patients with metastatic cSCC is poor emphasizing the need
Abstract In acute skin injury, healing is impaired by the excessive release of reactive oxygen species (ROS). Melanin, an efficient scavenger of radical species in
Highlights Summary PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream
RNA surveillance turns oncogenic Precise RNA regulation is a quality control mechanism that is important for normal development and to prevent disease. Aberrant RNAs require
Abstract BACKGROUND Whether pembrolizumab given both before surgery (neoadjuvant therapy) and after surgery (adjuvant therapy), as compared with pembrolizumab given as adjuvant therapy alone, would
Preventing progression A subset of patients with melanoma treated with PD-1 blockade develop hyperprogression, where disease progresses more rapidly after treatment. Here, Theivanthiran et al. aimed to determine
Abstract Tumour dependency on specific metabolic signals has been demonstrated and often guided numerous therapeutic approaches. We identify melanoma addiction to the mitochondrial protein glutaryl-CoA
Abstract A distinct profile of NRAS mutants is observed in each tumor type. It is unclear whether these profiles are determined by mutagenic events or
Abstract The therapeutic benefit of approved BRAF and MEK inhibitors (BRAFi/MEKi) in patients with brain metastatic BRAF V600E/K–mutated melanoma is limited and transient. Resistance largely
Abstract Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph node pre-metastatic
T argeted therapy and immunotherapy are often employed as a one-two punch to treat certain cancers, but sometimes this approach falls short. In a study
The incidence of melanoma has increased, but mortality has declined with improved management. Sentinel-node sampling has reduced morbidity associated with staging surgery, and treatment of
Despite the recent progress made in treating melanoma, an ongoing issue is the development of drug resistance to promising target-specific therapeutic strategies, resulting in treatment
New fecal microbiota for cancer patients The composition of the gut microbiome influences the response of cancer patients to immunotherapies. Baruch et al. and Davar et al. report first-in-human
In 2014, at Washington University School of Medicine in St. Louis, six melanoma patients received infusions of an anticancer vaccine composed of their own dendritic
Highlights • RAC1P29S activates PAK, AKT, and the SRF/MRTF transcription program in melanocytes • RAC1P29S induces a melanocytic to mesenchymal transition through SRF/MRTF and PAK
An experimental cancer vaccine that boosts the immune system’s ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumors,
Aging is a major risk factor for melanoma. Older patients are likely to develop more aggressive disease and usually respond poorly to treatment. Kugel et
Immunotherapy using checkpoint inhibitors has dramatically improved melanoma treatment response. However, only a subset of patients show durable remissions. Hong et al. studied circulating tumor
A strain of Staphylococcus epidermis found on human skin contains a chemical with cancer-fighting abilities, according to a study published yesterday (February 28) in Science
Obese men with metastatic melanoma who are treated using targeted or immuno-therapies survive for more than twice as long as patients receiving the same treatment,
Using a process called in situ vaccination, in which the host’s immune system is recruited to attack cancer cells, researchers were able to clear injected
Abstract Harnessing female sex hormones may improve how all patients with melanoma respond to treatment. Main text Melanoma is a deadly form of skin cancer
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